丹麦超重/肥胖与胃肠道疾病发病率-一项队列研究

IF 5.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Sigrid Bjerge Gribsholt, Dóra Körmendiné Farkas, Peter Jepsen, Bjørn Richelsen, Henrik Toft Sørensen
{"title":"丹麦超重/肥胖与胃肠道疾病发病率-一项队列研究","authors":"Sigrid Bjerge Gribsholt, Dóra Körmendiné Farkas, Peter Jepsen, Bjørn Richelsen, Henrik Toft Sørensen","doi":"10.1093/ejendo/lvaf077","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Obesity is associated with various gastrointestinal (GI) conditions. Because of the epidemic rise of obesity, we examined associations between overweight/obesity and incidence of individual GI diseases.</p><p><strong>Design: </strong>Cohort study.</p><p><strong>Setting: </strong>Denmark, 1997-2018.</p><p><strong>Participants: </strong>Using nationwide healthcare registries, we identified All Danes ≥18 years with a hospital diagnosis of overweight/obesity. We created an age- and sex-matched general population comparison cohort.</p><p><strong>Exposure: </strong>A diagnosis code of overweight/obesity.</p><p><strong>Main outcomes and measures: </strong>We compared the incidence of hospital-diagnosed GI diseases from 1 year after overweight/obesity diagnosis.</p><p><strong>Results: </strong>We included 129 466 patients with overweight/obesity (70.9% female, median age 49.3 years). Their incidence rate of GI disease was 30.1 per 1000 person years (95% CI: 29.8-30.5) vs 16.7 (95% CI: 16.5-16.8) for comparators, yielding an adjusted hazard ratio (aHR) of 1.7 (95% CI: 1.7-1.7). The aHRs indicated elevated risk of all GI disease sub-types in the overweight/obesity cohort, including cholelithiasis: 2.8 (95% CI: 2.7-2.9), cholecystitis: 2.6 (95% CI: 2.4-2.8), acute pancreatitis: 2.2 (95% CI: 2.0-2.4), stomach ulcer: 2.0 (95% CI: 1.9-2.1), cirrhosis: 1.5 (95% CI: 1.3-1.7), and obesity-associated GI cancer: 1.2 (95% CI: 1.2-1.3). The aHR for any GI disease was 1.4 (95% CI: 1.4-1.5) in men and 1.9 (95% CI: 1.8-1.9) in women. Among patients 18 to <30 years, the aHR was 2.6 (95% CI: 2.5-2.7) vs 1.3 (95% CI: 1.3-1.4) among individuals ≥70 years.</p><p><strong>Conclusions and relevance: </strong>Overweight/obesity is a risk factor for a wide range of GI diseases and is expected to become an even greater clinical challenge in the future.</p>","PeriodicalId":11884,"journal":{"name":"European Journal of Endocrinology","volume":"192 5","pages":"540-548"},"PeriodicalIF":5.3000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Overweight/obesity and gastrointestinal disease incidence in Denmark-a cohort study.\",\"authors\":\"Sigrid Bjerge Gribsholt, Dóra Körmendiné Farkas, Peter Jepsen, Bjørn Richelsen, Henrik Toft Sørensen\",\"doi\":\"10.1093/ejendo/lvaf077\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Obesity is associated with various gastrointestinal (GI) conditions. Because of the epidemic rise of obesity, we examined associations between overweight/obesity and incidence of individual GI diseases.</p><p><strong>Design: </strong>Cohort study.</p><p><strong>Setting: </strong>Denmark, 1997-2018.</p><p><strong>Participants: </strong>Using nationwide healthcare registries, we identified All Danes ≥18 years with a hospital diagnosis of overweight/obesity. We created an age- and sex-matched general population comparison cohort.</p><p><strong>Exposure: </strong>A diagnosis code of overweight/obesity.</p><p><strong>Main outcomes and measures: </strong>We compared the incidence of hospital-diagnosed GI diseases from 1 year after overweight/obesity diagnosis.</p><p><strong>Results: </strong>We included 129 466 patients with overweight/obesity (70.9% female, median age 49.3 years). Their incidence rate of GI disease was 30.1 per 1000 person years (95% CI: 29.8-30.5) vs 16.7 (95% CI: 16.5-16.8) for comparators, yielding an adjusted hazard ratio (aHR) of 1.7 (95% CI: 1.7-1.7). The aHRs indicated elevated risk of all GI disease sub-types in the overweight/obesity cohort, including cholelithiasis: 2.8 (95% CI: 2.7-2.9), cholecystitis: 2.6 (95% CI: 2.4-2.8), acute pancreatitis: 2.2 (95% CI: 2.0-2.4), stomach ulcer: 2.0 (95% CI: 1.9-2.1), cirrhosis: 1.5 (95% CI: 1.3-1.7), and obesity-associated GI cancer: 1.2 (95% CI: 1.2-1.3). The aHR for any GI disease was 1.4 (95% CI: 1.4-1.5) in men and 1.9 (95% CI: 1.8-1.9) in women. Among patients 18 to <30 years, the aHR was 2.6 (95% CI: 2.5-2.7) vs 1.3 (95% CI: 1.3-1.4) among individuals ≥70 years.</p><p><strong>Conclusions and relevance: </strong>Overweight/obesity is a risk factor for a wide range of GI diseases and is expected to become an even greater clinical challenge in the future.</p>\",\"PeriodicalId\":11884,\"journal\":{\"name\":\"European Journal of Endocrinology\",\"volume\":\"192 5\",\"pages\":\"540-548\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Endocrinology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ejendo/lvaf077\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Endocrinology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ejendo/lvaf077","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的:肥胖与多种胃肠道(GI)疾病有关。由于肥胖的流行上升,我们研究了超重/肥胖与个体胃肠道疾病发病率之间的关系。设计:队列研究。背景:丹麦,1997-2018。参与者:使用全国医疗保健登记,我们确定所有年龄≥18岁且医院诊断为超重/肥胖的丹麦人。我们创建了一个年龄和性别匹配的普通人群比较队列。暴露:超重/肥胖的诊断代码。主要结局和测量:我们比较了超重/肥胖诊断后1年内医院诊断的胃肠道疾病的发生率。结果:我们纳入了124966例超重/肥胖患者(70.9%为女性,中位年龄49.3岁)。他们的胃肠道疾病发病率为每1000人年30.1例(95% CI: 29.8-30.5),而比较组为16.7例(95% CI: 16.5-16.8),调整后的风险比(aHR)为1.7 (95% CI: 1.7-1.7)。ahr显示超重/肥胖队列中所有胃肠道疾病亚型的风险升高,包括胆石症:2.8 (95% CI: 2.7-2.9),胆囊炎:2.6 (95% CI: 2.4-2.8),急性胰腺炎:2.2 (95% CI: 2.0-2.4),胃溃疡:2.0 (95% CI: 1.9-2.1),肝硬化:1.5 (95% CI: 1.3-1.7)和肥胖相关胃肠道癌症:1.2 (95% CI: 1.2-1.3)。任何胃肠道疾病的aHR男性为1.4 (95% CI: 1.4-1.5),女性为1.9 (95% CI: 1.8-1.9)。结论及相关性:超重/肥胖是多种胃肠道疾病的危险因素,预计未来将成为更大的临床挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Overweight/obesity and gastrointestinal disease incidence in Denmark-a cohort study.

Objective: Obesity is associated with various gastrointestinal (GI) conditions. Because of the epidemic rise of obesity, we examined associations between overweight/obesity and incidence of individual GI diseases.

Design: Cohort study.

Setting: Denmark, 1997-2018.

Participants: Using nationwide healthcare registries, we identified All Danes ≥18 years with a hospital diagnosis of overweight/obesity. We created an age- and sex-matched general population comparison cohort.

Exposure: A diagnosis code of overweight/obesity.

Main outcomes and measures: We compared the incidence of hospital-diagnosed GI diseases from 1 year after overweight/obesity diagnosis.

Results: We included 129 466 patients with overweight/obesity (70.9% female, median age 49.3 years). Their incidence rate of GI disease was 30.1 per 1000 person years (95% CI: 29.8-30.5) vs 16.7 (95% CI: 16.5-16.8) for comparators, yielding an adjusted hazard ratio (aHR) of 1.7 (95% CI: 1.7-1.7). The aHRs indicated elevated risk of all GI disease sub-types in the overweight/obesity cohort, including cholelithiasis: 2.8 (95% CI: 2.7-2.9), cholecystitis: 2.6 (95% CI: 2.4-2.8), acute pancreatitis: 2.2 (95% CI: 2.0-2.4), stomach ulcer: 2.0 (95% CI: 1.9-2.1), cirrhosis: 1.5 (95% CI: 1.3-1.7), and obesity-associated GI cancer: 1.2 (95% CI: 1.2-1.3). The aHR for any GI disease was 1.4 (95% CI: 1.4-1.5) in men and 1.9 (95% CI: 1.8-1.9) in women. Among patients 18 to <30 years, the aHR was 2.6 (95% CI: 2.5-2.7) vs 1.3 (95% CI: 1.3-1.4) among individuals ≥70 years.

Conclusions and relevance: Overweight/obesity is a risk factor for a wide range of GI diseases and is expected to become an even greater clinical challenge in the future.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
European Journal of Endocrinology
European Journal of Endocrinology 医学-内分泌学与代谢
CiteScore
9.80
自引率
3.40%
发文量
354
审稿时长
1 months
期刊介绍: European Journal of Endocrinology is the official journal of the European Society of Endocrinology. Its predecessor journal is Acta Endocrinologica. The journal publishes high-quality original clinical and translational research papers and reviews in paediatric and adult endocrinology, as well as clinical practice guidelines, position statements and debates. Case reports will only be considered if they represent exceptional insights or advances in clinical endocrinology. Topics covered include, but are not limited to, Adrenal and Steroid, Bone and Mineral Metabolism, Hormones and Cancer, Pituitary and Hypothalamus, Thyroid and Reproduction. In the field of Diabetes, Obesity and Metabolism we welcome manuscripts addressing endocrine mechanisms of disease and its complications, management of obesity/diabetes in the context of other endocrine conditions, or aspects of complex disease management. Reports may encompass natural history studies, mechanistic studies, or clinical trials. Equal consideration is given to all manuscripts in English from any country.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信