SUMOylation在心脏病中的多面性及其治疗潜力。

IF 3.7 2区生物学 Q3 CELL BIOLOGY

Molecular and Cellular Biochemistry Pub Date : 2025-08-01 Epub Date: 2025-04-27 DOI:10.1007/s11010-025-05286-z

Ying He, Zhijie Yang, Dan Guo, Cheng Luo, Qiaoqiao Liu, Lei Xian, Fan Yang, Chusheng Huang, Qingjun Wei

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引用次数: 0

摘要

SUMOylation （SUMO）是一种重要的翻译后修饰，涉及多种生物过程的调节，在心脏功能的维持和心脏病的进展和治疗中起着关键作用。在这里，我们回顾了sumo与心功能和疾病的各个方面相关的机制，包括心脏肥厚、心力衰竭、缺血再灌注损伤和心肌梗死。此外，我们强调其作为治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The multifaceted nature of SUMOylation in heart disease and its therapeutic potential.

SUMOylation (SUMO), a crucial post-translational modification, is implicated in the regulation of diverse biological processes and plays a pivotal role in both the maintenance of cardiac function and progression and treatment of heart disease. Here, we reviewed the mechanisms by which SUMO-related various aspects of cardiac function and disease, including cardiac hypertrophy, heart failure, ischemia-reperfusion injury, and myocardial infarction. Furthermore, we highlight its potential as a therapeutic target.

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来源期刊

Molecular and Cellular Biochemistry 生物-细胞生物学

CiteScore

8.30

自引率

2.30%

发文量

293

审稿时长

1.7 months

期刊介绍： Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.