基于人群的乳腺癌发病率和死亡率分析:西班牙赫罗纳40年期间的总体和特定年龄的时间趋势

IF 3 3区 医学 Q2 ONCOLOGY
Breast Cancer Research and Treatment Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI:10.1007/s10549-025-07704-8
Arantza Sanvisens, Anna Vidal-Vila, Montse Puigdemont, Gemma Viñas, Ariadna Roqué-Lloveras, Sonia Del Barco, Ferran Pérez-Bueno, Jan Trallero, Rafael Marcos-Gragera, Gemma Renart
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引用次数: 0

摘要

目的:乳腺癌(BC)在女性中的发病率和死亡率随着时间的推移而变化。本研究旨在分析40年来人群水平的发病率和死亡率趋势。方法:赫罗纳癌症登记处开展的基于人群的BC研究,涵盖1980-2019年。计算年龄标准化发病率和死亡率。用泊松变点回归模型分析趋势,计算年变化百分比(APC)。结果:1980年至2019年间,共有12283例浸润性BC诊断。总年龄标准化发病率为109.9(95%置信区间(CI) 104.4;每10万妇女年115.4例。趋势分析显示,从1980年到1994年,发病率每年增加4.2% (95%CI 3.3;在1994年至2019年间趋于稳定,APC为0.28% (95%CI - 0.04;0.56)。0-49岁年龄组和50-69岁年龄组的趋势相似。在69岁以上的女性中,发病率增加4.4% (95%CI 2.8;在1980年至1995年期间,每年观察到6.0),随后无统计学意义地下降- 0.35% (95%CI - 0.86;0.15), 1995年至2019年。总年龄标准化死亡率为30.3 (95%CI 29.3;每10万名妇女中有31.3例。死亡率趋势显示有统计学意义的下降- 1.87% (95%CI - 2.38;- 1.37),自1992年以来每年。结论:女性BC发病率趋于稳定,BC死亡率逐渐下降。20世纪90年代中期引入乳房x光检查,加上筛查项目的早期发现和治疗,可能在减少所有年龄段妇女的BC负担方面发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Population-based analysis of breast cancer incidence and mortality: overall and age-specific temporal trends over 40-year period in Girona, Spain.

Purpose: Breast cancer (BC) incidence and mortality in women have changed over time. This study aims to analyze population-level incidence and mortality trends over 40 years of observation.

Methods: Population-based study of BC conducted by Girona Cancer Registry covering the period 1980-2019. Age-standardized incidence and mortality rates were calculated. Poisson change-point regression models were used to analyze trends, calculating the annual percentage change (APC).

Results: A total of 12,283 diagnoses of invasive BC between 1980 and 2019. The overall age-standardized incidence rate was 109.9 (95% confidence intervals (CI) 104.4; 115.4) cases per 100,000 women-years. Trend analyses showed a statistically significant incidence increase of 4.2% per year from 1980 to 1994 (95%CI 3.3; 5.1), and a stabilization between 1994 and 2019, with an APC of 0.28% (95%CI - 0.04; 0.56). These trends were similar for the age groups 0-49 years and 50-69 years. In women over 69 years of age, an increase in incidence of 4.4% (95%CI 2.8; 6.0) per year was observed between 1980 and 1995 followed by a non-statistically significant decrease of - 0.35% (95%CI - 0.86; 0.15) between 1995 and 2019. The overall age-standardized mortality rate was 30.3 (95%CI 29.3; 31.3) cases per 100,000 women-years. Mortality rate trends showed a statistically significant decrease of - 1.87% (95%CI - 2.38; - 1.37) per year since 1992.

Conclusion: There has been a stabilization in the incidence of BC and a gradual decline in BC mortality in women. The introduction of mammography in the mid-1990s, alongside early detection and treatment due to screening programs may play a significant role in the reduction of BC burden in women of all ages.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
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