血红蛋白刺激的巨噬细胞和斑块内出血在血管疾病发展中的作用。

IF 7.4 1区 医学 Q1 HEMATOLOGY
Atsushi Sakamoto, Alyssa Grogan, Rika Kawakami, Alexandra Finn, Palak Shah, Diya Nair, Krish Batra, Caroline Bailen, Mirai Sakamoto, Renu Virmani, Aloke V Finn
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引用次数: 0

摘要

斑块内出血在动脉粥样硬化斑块进展过程中起着至关重要的作用,不仅会引发病变大小的急性增加,还会吸引巨噬细胞到该部位。这些区域的红细胞溶解被认为是由氧化应激引起的,氧化应激诱导释放游离Hb(血红蛋白),Hb(血红蛋白)迅速与触珠蛋白结合形成Hb-触珠蛋白复合物。巨噬细胞是体内唯一能够通过CD(分化簇)163清道夫受体清除这些复合物的细胞,CD(分化簇)163清道夫受体介导hb -触珠蛋白的摄入,从而驱动它们的分化。新出现的数据表明,这些hb刺激的巨噬细胞通过介导铁代谢和影响其他细胞类型,包括内皮细胞和平滑肌细胞,在响应斑块内出血中发挥重要作用。本文综述了hb刺激巨噬细胞在促进动脉粥样硬化中的作用,主要通过以下方面进行阐述:(1)内皮细胞活化、新生血管生成和血管通透性;(2)内皮细胞向间充质细胞转化及随后的细胞凋亡;(3)防止平滑肌细胞成骨转化和钙化。这些功能也可能与其他血管疾病有关,其中红细胞积聚驱动hb刺激巨噬细胞的形成,这是对出血的基本反应,无论临床环境如何。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of Hemoglobin-Stimulated Macrophages and Intraplaque Hemorrhage in the Development of Vascular Diseases.

Intraplaque hemorrhage plays a critical role in the life of advancing atherosclerotic plaques, not only by triggering an acute increase in lesion size but also by attracting macrophages to the site. Lysis of erythrocytes in these areas is thought to be caused by oxidative stress, which induces the release of free Hb (hemoglobin), which is quickly bound by haptoglobin to form Hb-haptoglobin complexes. Macrophages are the only cells in the body capable of scavenging these complexes through the CD (cluster of differentiation) 163 scavenger receptor, which mediates Hb-haptoglobin ingestion, driving their differentiation. Emerging data suggest that these Hb-stimulated macrophages play an essential role in responding to intraplaque hemorrhage through mediating iron metabolism and influencing other cell types, including endothelial and smooth muscle cells. This review focuses on the role of Hb-stimulated macrophages in promoting atherogenesis through their effects on (1) endothelial activation, neoangiogenesis, and vascular permeability; (2) endothelial-to-mesenchymal cell transition and subsequent apoptosis; and (3) the prevention of smooth muscle cell osteogenic transformation and calcification. These functions may also be relevant to other vascular diseases where erythrocyte accumulation drives the formation of Hb-stimulated macrophages, which is a fundamental response to hemorrhage no matter the clinical setting.

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来源期刊
CiteScore
15.60
自引率
2.30%
发文量
337
审稿时长
2-4 weeks
期刊介绍: The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA). The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.
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