牛皮癣患者的人口统计学、临床特征和治疗模式：来自沙特阿拉伯牛皮癣登记处（PSORSA）的见解。

IF 3.5 3区医学 Q1 DERMATOLOGY

Dermatology and Therapy Pub Date : 2025-08-01 Epub Date: 2025-05-14 DOI:10.1007/s13555-025-01436-9

Mohammad Ibrahim Fatani, Yousef Binamer, Hajer Y Almudaiheem, Maysa Tariq Eshmawi, Fawaz Hamdi Aljehani, Sultanah Alshammari, Ahmed H Al-Jedai

{"title":"牛皮癣患者的人口统计学、临床特征和治疗模式：来自沙特阿拉伯牛皮癣登记处（PSORSA）的见解。","authors":"Mohammad Ibrahim Fatani, Yousef Binamer, Hajer Y Almudaiheem, Maysa Tariq Eshmawi, Fawaz Hamdi Aljehani, Sultanah Alshammari, Ahmed H Al-Jedai","doi":"10.1007/s13555-025-01436-9","DOIUrl":null,"url":null,"abstract":"Introduction: Psoriasis is a chronic immune-mediated inflammatory disease characterized by significant variability in clinical presentation and associated comorbidities. We aimed to describe the baseline demographic and clinical characteristics of patients with psoriasis enrolled in the Psoriasis Registry in Saudi Arabia (PSORSA).Methods: This multicenter cohort study included patients with moderate-to-severe psoriasis from 40 hospitals in Saudi Arabia. Baseline demographics, clinical, and comorbidity data were collected and analyzed. Follow-up assessments were conducted every three months for one year.Results: In total, 482 patients were enrolled. The mean age at diagnosis was 32.2 years, with a median disease duration of 848 days and a mean body mass index of 27.32 kg/m2. Male patients comprised 51.8% of the cohort, and 96.5% were Saudi nationals. A positive family history of psoriasis was reported in 17.2% of the participants. A total of 83 patients (17.2%) were documented to have comorbidities. Among these 83 patients, 47 (56.6%) had psoriatic arthritis, 20 (24.1%) had diabetes, and 14 (16.9%) had hypertension. Plaque psoriasis was the most common subtype (94.2%), and the most affected body regions were the upper and lower extremities (88.1% and 85.5%, respectively), followed by the scalp and trunk (75.7% each). The mean PASI score at baseline was 25 ± 13.3, which decreased to 0.32 ± 0.94 by week > 52. Conventional systemic therapies were prescribed to 22.6% of the patients, with methotrexate being the most common agent (18%). Biologic therapies were prescribed to 28.9% of the patients, with adalimumab being the most commonly used (21%). In addition, 12.7% of the cohort received phototherapy. Adverse events occurred in 2.1% of the patients, with cyclosporine contributing to 25% of the reported events.Conclusion: The PSORSA registry provides valuable insights into the demographics, clinical characteristics, and treatment patterns of patients with psoriasis in Saudi Arabia. These findings emphasize the need for real-world data to guide regional psoriasis management strategies.","PeriodicalId":11186,"journal":{"name":"Dermatology and Therapy","volume":" ","pages":"2031-2045"},"PeriodicalIF":3.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256395/pdf/","citationCount":"0","resultStr":"{\"title\":\"Demographics, Clinical Characteristics, and Treatment Patterns in Patients with Psoriasis: Insights from the Saudi Arabia Psoriasis Registry (PSORSA).\",\"authors\":\"Mohammad Ibrahim Fatani, Yousef Binamer, Hajer Y Almudaiheem, Maysa Tariq Eshmawi, Fawaz Hamdi Aljehani, Sultanah Alshammari, Ahmed H Al-Jedai\",\"doi\":\"10.1007/s13555-025-01436-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Psoriasis is a chronic immune-mediated inflammatory disease characterized by significant variability in clinical presentation and associated comorbidities. We aimed to describe the baseline demographic and clinical characteristics of patients with psoriasis enrolled in the Psoriasis Registry in Saudi Arabia (PSORSA).Methods: This multicenter cohort study included patients with moderate-to-severe psoriasis from 40 hospitals in Saudi Arabia. Baseline demographics, clinical, and comorbidity data were collected and analyzed. Follow-up assessments were conducted every three months for one year.Results: In total, 482 patients were enrolled. The mean age at diagnosis was 32.2 years, with a median disease duration of 848 days and a mean body mass index of 27.32 kg/m2. Male patients comprised 51.8% of the cohort, and 96.5% were Saudi nationals. A positive family history of psoriasis was reported in 17.2% of the participants. A total of 83 patients (17.2%) were documented to have comorbidities. Among these 83 patients, 47 (56.6%) had psoriatic arthritis, 20 (24.1%) had diabetes, and 14 (16.9%) had hypertension. Plaque psoriasis was the most common subtype (94.2%), and the most affected body regions were the upper and lower extremities (88.1% and 85.5%, respectively), followed by the scalp and trunk (75.7% each). The mean PASI score at baseline was 25 ± 13.3, which decreased to 0.32 ± 0.94 by week > 52. Conventional systemic therapies were prescribed to 22.6% of the patients, with methotrexate being the most common agent (18%). Biologic therapies were prescribed to 28.9% of the patients, with adalimumab being the most commonly used (21%). In addition, 12.7% of the cohort received phototherapy. Adverse events occurred in 2.1% of the patients, with cyclosporine contributing to 25% of the reported events.Conclusion: The PSORSA registry provides valuable insights into the demographics, clinical characteristics, and treatment patterns of patients with psoriasis in Saudi Arabia. These findings emphasize the need for real-world data to guide regional psoriasis management strategies.\",\"PeriodicalId\":11186,\"journal\":{\"name\":\"Dermatology and Therapy\",\"volume\":\" \",\"pages\":\"2031-2045\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256395/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dermatology and Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13555-025-01436-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"DERMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dermatology and Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13555-025-01436-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

银屑病是一种慢性免疫介导的炎症性疾病，其临床表现和相关合并症具有显著的可变性。我们的目的是描述在沙特阿拉伯牛皮癣登记处（PSORSA）登记的牛皮癣患者的基线人口统计学和临床特征。方法：这项多中心队列研究纳入了来自沙特阿拉伯40家医院的中重度牛皮癣患者。收集和分析基线人口统计学、临床和合并症数据。随访评估每三个月进行一次，持续一年。结果：共纳入482例患者。确诊时的平均年龄为32.2岁，中位病程为848天，平均体重指数为27.32 kg/m2。男性患者占队列的51.8%，96.5%为沙特国民。17.2%的参与者报告有银屑病阳性家族史。共有83例患者（17.2%）被记录有合并症。83例患者中，银屑病关节炎47例（56.6%），糖尿病20例（24.1%），高血压14例（16.9%）。斑块型银屑病是最常见的亚型（94.2%），发病部位以上肢和下肢为主（分别为88.1%和85.5%），其次为头皮和躯干（各为75.7%）。基线时PASI平均评分为25±13.3，到52周时降至0.32±0.94。22.6%的患者接受常规全身治疗，其中甲氨蝶呤是最常见的药物（18%）。28.9%的患者接受了生物治疗，阿达木单抗是最常用的（21%）。此外，12.7%的队列患者接受了光疗。不良事件发生在2.1%的患者中，环孢素占报告事件的25%。结论：PSORSA登记为沙特阿拉伯牛皮癣患者的人口统计学、临床特征和治疗模式提供了有价值的见解。这些发现强调需要真实世界的数据来指导区域牛皮癣管理策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Demographics, Clinical Characteristics, and Treatment Patterns in Patients with Psoriasis: Insights from the Saudi Arabia Psoriasis Registry (PSORSA).

Introduction: Psoriasis is a chronic immune-mediated inflammatory disease characterized by significant variability in clinical presentation and associated comorbidities. We aimed to describe the baseline demographic and clinical characteristics of patients with psoriasis enrolled in the Psoriasis Registry in Saudi Arabia (PSORSA).

Methods: This multicenter cohort study included patients with moderate-to-severe psoriasis from 40 hospitals in Saudi Arabia. Baseline demographics, clinical, and comorbidity data were collected and analyzed. Follow-up assessments were conducted every three months for one year.

Results: In total, 482 patients were enrolled. The mean age at diagnosis was 32.2 years, with a median disease duration of 848 days and a mean body mass index of 27.32 kg/m². Male patients comprised 51.8% of the cohort, and 96.5% were Saudi nationals. A positive family history of psoriasis was reported in 17.2% of the participants. A total of 83 patients (17.2%) were documented to have comorbidities. Among these 83 patients, 47 (56.6%) had psoriatic arthritis, 20 (24.1%) had diabetes, and 14 (16.9%) had hypertension. Plaque psoriasis was the most common subtype (94.2%), and the most affected body regions were the upper and lower extremities (88.1% and 85.5%, respectively), followed by the scalp and trunk (75.7% each). The mean PASI score at baseline was 25 ± 13.3, which decreased to 0.32 ± 0.94 by week > 52. Conventional systemic therapies were prescribed to 22.6% of the patients, with methotrexate being the most common agent (18%). Biologic therapies were prescribed to 28.9% of the patients, with adalimumab being the most commonly used (21%). In addition, 12.7% of the cohort received phototherapy. Adverse events occurred in 2.1% of the patients, with cyclosporine contributing to 25% of the reported events.

Conclusion: The PSORSA registry provides valuable insights into the demographics, clinical characteristics, and treatment patterns of patients with psoriasis in Saudi Arabia. These findings emphasize the need for real-world data to guide regional psoriasis management strategies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Dermatology and Therapy Medicine-Dermatology

CiteScore

6.00

自引率

8.80%

发文量

187

审稿时长

6 weeks

期刊介绍： Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.