{"title":"评估间充质干细胞治疗脊髓损伤：系统回顾和网络荟萃分析。","authors":"Runfang Wang, Yiding Wang, Fangning Yan, Jinqing Sun, Tianyu Zhang","doi":"10.3389/fncel.2025.1532219","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to explore the clinical efficacy of mesenchymal stem cell (MSC) transplantation in the treatment of patients with spinal cord injury (SCI) through a network meta-analysis and to discuss the optimal transplantation strategy for treatment.</p><p><strong>Methods: </strong>We conducted a computer search of clinical randomized controlled studies on MSC treatment for SCI in databases including PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), Wanfang Database, and Chinese Biomedical Literature Service System (SinoMed) up to March 2024. Two researchers independently completed literature screening and data extraction according to the inclusion and exclusion criteria and used RevMan 5.4 software to assess the quality of the included studies. Network meta-analysis was performed using Stata 16.0 software.</p><p><strong>Results: </strong>A total of 18 studies were included in the analysis. The results showed that MSCs significantly improved motor, sensory, and activities of daily living activities after SCI. Network meta-analysis indicated that umbilical cord mesenchymal stem cells (UCMSCs) were the most effective cell source, and intrathecal injection (IT) was the optimal transplantation method.</p><p><strong>Conclusion: </strong>The study suggests that the current use of UCMSCs for IT transplantation may be the best transplantation strategy for improving functional impairment after SCI. Further high-quality studies are still needed to validate the results of this study and to ensure the reliability of the results.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier [CRD42023466102].</p>","PeriodicalId":12432,"journal":{"name":"Frontiers in Cellular Neuroscience","volume":"19 ","pages":"1532219"},"PeriodicalIF":4.2000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040839/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis.\",\"authors\":\"Runfang Wang, Yiding Wang, Fangning Yan, Jinqing Sun, Tianyu Zhang\",\"doi\":\"10.3389/fncel.2025.1532219\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to explore the clinical efficacy of mesenchymal stem cell (MSC) transplantation in the treatment of patients with spinal cord injury (SCI) through a network meta-analysis and to discuss the optimal transplantation strategy for treatment.</p><p><strong>Methods: </strong>We conducted a computer search of clinical randomized controlled studies on MSC treatment for SCI in databases including PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), Wanfang Database, and Chinese Biomedical Literature Service System (SinoMed) up to March 2024. 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引用次数: 0
摘要
目的：本研究旨在通过网络meta分析，探讨间充质干细胞（MSC）移植治疗脊髓损伤（SCI）患者的临床疗效，并探讨最佳移植治疗策略。方法：计算机检索截至2024年3月PubMed、Web of Science、Cochrane Library、Embase、中国知网（CNKI）、中国科技期刊库（VIP）、万方数据库、中国生物医学文献服务系统（SinoMed）等数据库中MSC治疗SCI的临床随机对照研究。2名研究者按照纳入和排除标准独立完成文献筛选和资料提取，并使用RevMan 5.4软件对纳入研究的质量进行评价。采用Stata 16.0软件进行网络meta分析。结果：共纳入18项研究。结果显示，MSCs显著改善脊髓损伤后的运动、感觉和日常生活活动能力。网络荟萃分析显示脐带间充质干细胞（UCMSCs）是最有效的细胞来源，鞘内注射（IT）是最理想的移植方法。结论：该研究表明，目前使用UCMSCs进行IT移植可能是改善脊髓损伤后功能损伤的最佳移植策略。仍需要进一步的高质量研究来验证本研究的结果并确保结果的可靠性。系统评价注册：https://www.crd.york.ac.uk/prospero/，标识符[CRD42023466102]。
Assessment of mesenchymal stem cells for the treatment of spinal cord injury: a systematic review and network meta-analysis.
Objective: This study aims to explore the clinical efficacy of mesenchymal stem cell (MSC) transplantation in the treatment of patients with spinal cord injury (SCI) through a network meta-analysis and to discuss the optimal transplantation strategy for treatment.
Methods: We conducted a computer search of clinical randomized controlled studies on MSC treatment for SCI in databases including PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP), Wanfang Database, and Chinese Biomedical Literature Service System (SinoMed) up to March 2024. Two researchers independently completed literature screening and data extraction according to the inclusion and exclusion criteria and used RevMan 5.4 software to assess the quality of the included studies. Network meta-analysis was performed using Stata 16.0 software.
Results: A total of 18 studies were included in the analysis. The results showed that MSCs significantly improved motor, sensory, and activities of daily living activities after SCI. Network meta-analysis indicated that umbilical cord mesenchymal stem cells (UCMSCs) were the most effective cell source, and intrathecal injection (IT) was the optimal transplantation method.
Conclusion: The study suggests that the current use of UCMSCs for IT transplantation may be the best transplantation strategy for improving functional impairment after SCI. Further high-quality studies are still needed to validate the results of this study and to ensure the reliability of the results.
期刊介绍：
Frontiers in Cellular Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species. Specialty Chief Editors Egidio D‘Angelo at the University of Pavia and Christian Hansel at the University of Chicago are supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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