口服铁片对小鼠上消化道运动迟缓的影响。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Syunki Yamada, Taiki Mihara, Tamaki Kurosawa, Aya Maruyama, Katsuyo Ohashi-Doi, Yuko Mitobe, Masatoshi Hori
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引用次数: 0

摘要

口服铁制剂治疗缺铁性贫血有严重的副作用,如恶心和呕吐,这是众所周知的胃肠道运动障碍的胃肠道症状。然而,尚不清楚这些症状是否与胃肠蠕动有关。本研究旨在探讨口服铁制剂引起恶心和呕吐与胃肠运动的关系。柠檬酸亚铁钠(SFC)是铁制剂中常见的一种原料。用13c -辛酸呼气试验测定小鼠胃肠运动,用排珠试验测定胃排空和结肠运输能力。SFC显著延迟胃排空。但不影响结肠的运输能力。用抗吐帕洛诺司琼(一种5-羟色胺3 (5-HT3)受体抑制剂)治疗可消除SFC的胃排空阻滞作用,但SFC制剂中的添加剂帕洛诺司琼单独使用不影响胃排空能力。这些结果表明铁制剂引起上消化道迷走性恶心和呕吐,这是由于对胃肠道血液的化学刺激,同时胃排空能力降低。了解胃排空延迟与铁诱导恶心发作的关系有助于了解铁诱导的不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Delayed Upper Gastrointestinal Motility in Mice Treated with Oral Iron Tablets.

Oral iron preparations for iron deficiency anemia have major side effects, such as nausea and vomiting, which are gastrointestinal symptoms widely known to occur with gastrointestinal motility disorders. However, it is unclear whether these symptoms are associated with gastrointestinal motility. This study aimed to explore the correlation between oral iron preparations that cause nausea and vomiting with gastrointestinal motility. Sodium ferrous citrate (SFC), a common ingredient in iron preparations, was used in this study. Gastrointestinal motility in mice was measured using the 13C-octanoic acid breath test to determine gastric emptying and colonic transport capacities using the bead expulsion test. SFC significantly delayed gastric emptying. However, it did not affect the colonic transport capacity. Treatment with the antiemetic palonosetron, a 5-hydroxytryptamine 3 (5-HT3) receptor inhibitor, abolished the gastric evacuation retardation effect of SFC. However, the additive in the SFC formulation, palonosetron alone, did not affect the gastric emptying capacity. These results suggest that iron preparations cause vagal nausea and vomiting in the upper gastrointestinal tract due to chemical stimulation of the gastrointestinal blood with a concomitant reduction in gastric emptying capacity. Knowledge of the association of delayed gastric emptying with the onset of iron-induced nausea is useful for understanding iron-induced adverse effects.

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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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