首先,乳房x光检查发现的癌症预示着被诊断患有乳腺癌的年轻女性的生存率更低。

IF 3 3区 医学 Q2 ONCOLOGY
Breast Cancer Research and Treatment Pub Date : 2025-07-01 Epub Date: 2025-04-25 DOI:10.1007/s10549-025-07703-9
Avia D Wilkerson, Megan Obi, Corey Gentle, Wei Wei, Camila Ortega, Zahraa Al-Hilli
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引用次数: 0

摘要

目的:针对40-45岁女性的乳腺癌(BC)筛查指南在多个组织中有所不同,导致美国女性开始筛查的年龄不同。我们之前报道过,40岁以后延迟筛查会增加首次乳房x光检查诊断癌症的风险。我们假设首次乳房x光检查癌症也可能降低无复发和总生存率(RFS, OS)。研究设计:这项回顾性队列研究包括738名年龄在40-45岁之间诊断为BC的女性,并于2010年至2019年在单一医院系统内接受治疗。首次乳房x光检查癌症被定义为在基线乳房x光检查后3个月内确定组织诊断的癌症。通过Kaplan-Meier方法分析首次和后续乳房x光检查诊断的患者术后RFS和BC诊断后OS, p值由log rank检验产生。还评估了局部和远处复发的累积发生率。结果:在738名妇女中,218名首次乳房x光检查患有癌症,520名在随后的乳房x光检查中被诊断出患有癌症。中位随访时间为72.2个月(0.5 ~ 155.8个月)。在诊断后5年和10年,首次乳房x光检查诊断的患者的OS(0.88[0.83-0.93]和0.80[0.73-0.87])明显差于后续乳房x光检查(0.95[0.93-0.97]和0.90 [0.86-0.93]),p = 0.003。首次乳房x光检查的癌症患者5年和10年的RFS率也较低(0.81[0.71-0.88]和0.74[0.65-0.83]比0.88[0.85-0.92]和0.77 [0.72-0.83]),p = 0.04。结论:在我们的研究队列中,首先乳房x光检查癌症与较差的生存率相关,这加强了40岁开始筛查的一致性指南的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
First mammogram-detected cancers portend worse survival in young women diagnosed with breast cancer.

Purpose: Breast cancer (BC) screening guidelines for women ages 40-45 have differed across multiple organizations, resulting in variable ages of screening commencement among women in the US. We previously reported that delay in screening beyond age 40 increases risk for first mammogram cancer diagnoses. We hypothesize that first mammogram cancer detection may also diminish recurrence-free and overall survival (RFS, OS).

Study design: This retrospective cohort study included 738 women diagnosed with BC from ages 40-45 years and treated within a single hospital system from 2010 to 2019. First mammogram cancers were defined as those with tissue diagnoses established within 3 months of baseline mammogram. RFS after surgery and OS after BC diagnosis were analyzed in patients diagnosed on first versus subsequent mammograms via the Kaplan-Meier method, with p-values generated by log rank tests. Cumulative incidences of local and distant recurrence were also assessed.

Results: Of 738 women, 218 had first mammogram cancers while 520 were diagnosed on subsequent mammograms. Median follow-up was 72.2 months (0.5-155.8 months). At 5 and 10 years after diagnosis, OS was significantly worse in patients diagnosed on their first mammogram (0.88 [0.83-0.93] and 0.80 [0.73-0.87]) versus subsequent mammograms (0.95 [0.93-0.97] and 0.90 [0.86-0.93]), p = 0.003. Patients with first mammogram cancers also had inferior 5- and 10-years RFS rates (0.81 [0.71-0.88] and 0.74 [0.65-0.83] vs. 0.88 [0.85-0.92] and 0.77 [0.72-0.83]), p = 0.04.

Conclusion: First mammogram cancers were associated with worse survival in our study cohort, reinforcing the importance of consistent guidelines for screening commencement at age 40.

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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
342
审稿时长
1 months
期刊介绍: Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.
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