{"title":"首先,乳房x光检查发现的癌症预示着被诊断患有乳腺癌的年轻女性的生存率更低。","authors":"Avia D Wilkerson, Megan Obi, Corey Gentle, Wei Wei, Camila Ortega, Zahraa Al-Hilli","doi":"10.1007/s10549-025-07703-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Breast cancer (BC) screening guidelines for women ages 40-45 have differed across multiple organizations, resulting in variable ages of screening commencement among women in the US. We previously reported that delay in screening beyond age 40 increases risk for first mammogram cancer diagnoses. We hypothesize that first mammogram cancer detection may also diminish recurrence-free and overall survival (RFS, OS).</p><p><strong>Study design: </strong>This retrospective cohort study included 738 women diagnosed with BC from ages 40-45 years and treated within a single hospital system from 2010 to 2019. First mammogram cancers were defined as those with tissue diagnoses established within 3 months of baseline mammogram. RFS after surgery and OS after BC diagnosis were analyzed in patients diagnosed on first versus subsequent mammograms via the Kaplan-Meier method, with p-values generated by log rank tests. Cumulative incidences of local and distant recurrence were also assessed.</p><p><strong>Results: </strong>Of 738 women, 218 had first mammogram cancers while 520 were diagnosed on subsequent mammograms. Median follow-up was 72.2 months (0.5-155.8 months). At 5 and 10 years after diagnosis, OS was significantly worse in patients diagnosed on their first mammogram (0.88 [0.83-0.93] and 0.80 [0.73-0.87]) versus subsequent mammograms (0.95 [0.93-0.97] and 0.90 [0.86-0.93]), p = 0.003. Patients with first mammogram cancers also had inferior 5- and 10-years RFS rates (0.81 [0.71-0.88] and 0.74 [0.65-0.83] vs. 0.88 [0.85-0.92] and 0.77 [0.72-0.83]), p = 0.04.</p><p><strong>Conclusion: </strong>First mammogram cancers were associated with worse survival in our study cohort, reinforcing the importance of consistent guidelines for screening commencement at age 40.</p>","PeriodicalId":9133,"journal":{"name":"Breast Cancer Research and Treatment","volume":" ","pages":"87-95"},"PeriodicalIF":3.0000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086120/pdf/","citationCount":"0","resultStr":"{\"title\":\"First mammogram-detected cancers portend worse survival in young women diagnosed with breast cancer.\",\"authors\":\"Avia D Wilkerson, Megan Obi, Corey Gentle, Wei Wei, Camila Ortega, Zahraa Al-Hilli\",\"doi\":\"10.1007/s10549-025-07703-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Breast cancer (BC) screening guidelines for women ages 40-45 have differed across multiple organizations, resulting in variable ages of screening commencement among women in the US. We previously reported that delay in screening beyond age 40 increases risk for first mammogram cancer diagnoses. We hypothesize that first mammogram cancer detection may also diminish recurrence-free and overall survival (RFS, OS).</p><p><strong>Study design: </strong>This retrospective cohort study included 738 women diagnosed with BC from ages 40-45 years and treated within a single hospital system from 2010 to 2019. First mammogram cancers were defined as those with tissue diagnoses established within 3 months of baseline mammogram. RFS after surgery and OS after BC diagnosis were analyzed in patients diagnosed on first versus subsequent mammograms via the Kaplan-Meier method, with p-values generated by log rank tests. Cumulative incidences of local and distant recurrence were also assessed.</p><p><strong>Results: </strong>Of 738 women, 218 had first mammogram cancers while 520 were diagnosed on subsequent mammograms. Median follow-up was 72.2 months (0.5-155.8 months). At 5 and 10 years after diagnosis, OS was significantly worse in patients diagnosed on their first mammogram (0.88 [0.83-0.93] and 0.80 [0.73-0.87]) versus subsequent mammograms (0.95 [0.93-0.97] and 0.90 [0.86-0.93]), p = 0.003. Patients with first mammogram cancers also had inferior 5- and 10-years RFS rates (0.81 [0.71-0.88] and 0.74 [0.65-0.83] vs. 0.88 [0.85-0.92] and 0.77 [0.72-0.83]), p = 0.04.</p><p><strong>Conclusion: </strong>First mammogram cancers were associated with worse survival in our study cohort, reinforcing the importance of consistent guidelines for screening commencement at age 40.</p>\",\"PeriodicalId\":9133,\"journal\":{\"name\":\"Breast Cancer Research and Treatment\",\"volume\":\" \",\"pages\":\"87-95\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086120/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Breast Cancer Research and Treatment\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s10549-025-07703-9\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Breast Cancer Research and Treatment","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10549-025-07703-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
First mammogram-detected cancers portend worse survival in young women diagnosed with breast cancer.
Purpose: Breast cancer (BC) screening guidelines for women ages 40-45 have differed across multiple organizations, resulting in variable ages of screening commencement among women in the US. We previously reported that delay in screening beyond age 40 increases risk for first mammogram cancer diagnoses. We hypothesize that first mammogram cancer detection may also diminish recurrence-free and overall survival (RFS, OS).
Study design: This retrospective cohort study included 738 women diagnosed with BC from ages 40-45 years and treated within a single hospital system from 2010 to 2019. First mammogram cancers were defined as those with tissue diagnoses established within 3 months of baseline mammogram. RFS after surgery and OS after BC diagnosis were analyzed in patients diagnosed on first versus subsequent mammograms via the Kaplan-Meier method, with p-values generated by log rank tests. Cumulative incidences of local and distant recurrence were also assessed.
Results: Of 738 women, 218 had first mammogram cancers while 520 were diagnosed on subsequent mammograms. Median follow-up was 72.2 months (0.5-155.8 months). At 5 and 10 years after diagnosis, OS was significantly worse in patients diagnosed on their first mammogram (0.88 [0.83-0.93] and 0.80 [0.73-0.87]) versus subsequent mammograms (0.95 [0.93-0.97] and 0.90 [0.86-0.93]), p = 0.003. Patients with first mammogram cancers also had inferior 5- and 10-years RFS rates (0.81 [0.71-0.88] and 0.74 [0.65-0.83] vs. 0.88 [0.85-0.92] and 0.77 [0.72-0.83]), p = 0.04.
Conclusion: First mammogram cancers were associated with worse survival in our study cohort, reinforcing the importance of consistent guidelines for screening commencement at age 40.
期刊介绍:
Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. The journal creates a "market place" for breast cancer topics which cuts across all the usual lines of disciplines, providing a site for presenting pertinent investigations, and for discussing critical questions relevant to the entire field. It seeks to develop a new focus and new perspectives for all those concerned with breast cancer.