{"title":"OR1F1蛋白高表达作为食管鳞状细胞癌的潜在预后生物标志物","authors":"Shunsuke Yamagishi, Mitsuro Kanda, Takahiro Shinozuka, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Haruyoshi Tanaka, Hideki Takami, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera, Yukiyasu Okamura","doi":"10.21873/anticanres.17575","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aim: </strong>In patients with esophageal squamous cell carcinoma (ESCC), the identification of biomarkers that enable precise stratification of postoperative prognostic risk is crucial for developing personalized treatment strategies. Biomarker reproducibility across multiple independent cohorts is a key consideration in biomarker discovery.</p><p><strong>Materials and methods: </strong>Transcriptome analysis was performed on primary tumor tissues from patients with ESCC who experienced recurrence in distant organs, thus identifying olfactory receptor family 1 subfamily F member 1 (OR1F1) as a candidate biomarker. OR1F1 protein expression and prognostic value were analyzed in two independent cohorts of patients with ESCC who underwent curative esophagectomy using immunohistochemical staining.</p><p><strong>Results: </strong>In Cohort 1, high expression of OR1F1 protein in ESCC tissues was significantly correlated with reduced overall survival (OS) and disease-free survival (DFS). Multivariate analysis of OS after surgery identified high OR1F1 protein expression as an independent adverse prognostic factor. Likewise, high OR1F1 protein expression in tissues was strongly associated with reduced OS and DFS in Cohort 2. In both cohorts, patient prognosis could be stratified into three distinct risk levels based on the expression level of OR1F1 protein.</p><p><strong>Conclusion: </strong>Tissue OR1F1 protein expression could serve as a valuable prognostic biomarker for patients with ESCC.</p>","PeriodicalId":8072,"journal":{"name":"Anticancer research","volume":"45 5","pages":"1997-2009"},"PeriodicalIF":1.6000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High Expression of OR1F1 Protein as a Potential Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.\",\"authors\":\"Shunsuke Yamagishi, Mitsuro Kanda, Takahiro Shinozuka, Yusuke Sato, Dai Shimizu, Chie Tanaka, Shinichi Umeda, Haruyoshi Tanaka, Hideki Takami, Norifumi Hattori, Masamichi Hayashi, Goro Nakayama, Yasuhiro Kodera, Yukiyasu Okamura\",\"doi\":\"10.21873/anticanres.17575\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background/aim: </strong>In patients with esophageal squamous cell carcinoma (ESCC), the identification of biomarkers that enable precise stratification of postoperative prognostic risk is crucial for developing personalized treatment strategies. Biomarker reproducibility across multiple independent cohorts is a key consideration in biomarker discovery.</p><p><strong>Materials and methods: </strong>Transcriptome analysis was performed on primary tumor tissues from patients with ESCC who experienced recurrence in distant organs, thus identifying olfactory receptor family 1 subfamily F member 1 (OR1F1) as a candidate biomarker. OR1F1 protein expression and prognostic value were analyzed in two independent cohorts of patients with ESCC who underwent curative esophagectomy using immunohistochemical staining.</p><p><strong>Results: </strong>In Cohort 1, high expression of OR1F1 protein in ESCC tissues was significantly correlated with reduced overall survival (OS) and disease-free survival (DFS). Multivariate analysis of OS after surgery identified high OR1F1 protein expression as an independent adverse prognostic factor. Likewise, high OR1F1 protein expression in tissues was strongly associated with reduced OS and DFS in Cohort 2. In both cohorts, patient prognosis could be stratified into three distinct risk levels based on the expression level of OR1F1 protein.</p><p><strong>Conclusion: </strong>Tissue OR1F1 protein expression could serve as a valuable prognostic biomarker for patients with ESCC.</p>\",\"PeriodicalId\":8072,\"journal\":{\"name\":\"Anticancer research\",\"volume\":\"45 5\",\"pages\":\"1997-2009\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Anticancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21873/anticanres.17575\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anticancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/anticanres.17575","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
High Expression of OR1F1 Protein as a Potential Prognostic Biomarker for Esophageal Squamous Cell Carcinoma.
Background/aim: In patients with esophageal squamous cell carcinoma (ESCC), the identification of biomarkers that enable precise stratification of postoperative prognostic risk is crucial for developing personalized treatment strategies. Biomarker reproducibility across multiple independent cohorts is a key consideration in biomarker discovery.
Materials and methods: Transcriptome analysis was performed on primary tumor tissues from patients with ESCC who experienced recurrence in distant organs, thus identifying olfactory receptor family 1 subfamily F member 1 (OR1F1) as a candidate biomarker. OR1F1 protein expression and prognostic value were analyzed in two independent cohorts of patients with ESCC who underwent curative esophagectomy using immunohistochemical staining.
Results: In Cohort 1, high expression of OR1F1 protein in ESCC tissues was significantly correlated with reduced overall survival (OS) and disease-free survival (DFS). Multivariate analysis of OS after surgery identified high OR1F1 protein expression as an independent adverse prognostic factor. Likewise, high OR1F1 protein expression in tissues was strongly associated with reduced OS and DFS in Cohort 2. In both cohorts, patient prognosis could be stratified into three distinct risk levels based on the expression level of OR1F1 protein.
Conclusion: Tissue OR1F1 protein expression could serve as a valuable prognostic biomarker for patients with ESCC.
期刊介绍：
ANTICANCER RESEARCH is an independent international peer-reviewed journal devoted to the rapid publication of high quality original articles and reviews on all aspects of experimental and clinical oncology. Prompt evaluation of all submitted articles in confidence and rapid publication within 1-2 months of acceptance are guaranteed.
ANTICANCER RESEARCH was established in 1981 and is published monthly (bimonthly until the end of 2008). Each annual volume contains twelve issues and index. Each issue may be divided into three parts (A: Reviews, B: Experimental studies, and C: Clinical and Epidemiological studies).
Special issues, presenting the proceedings of meetings or groups of papers on topics of significant progress, will also be included in each volume. There is no limitation to the number of pages per issue.
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