预测子痫前期血栓形成:是否有必要进行普遍检测?

IF 2.3 4区 医学 Q2 HEMATOLOGY
Ana Belén Gálvez, Pedro Chorão, Ernesto M Talegón, María Del Carmen Gilabert, Amando Blanquer, Fernando Ferrando, Ana Cid, Antonio Moscardó, Saturnino Haya, Santiago Bonanad
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引用次数: 0

摘要

血栓病(TP)被认为是子痫前期(PE)的潜在诱因。然而,由于相互矛盾的证据,对PE患者进行TP检测并没有明确的共识。本研究旨在确定哪些PE女性与获得性和遗传性TP相关,并利用这些特征建立TP概率模型。材料和方法回顾性单中心分析2019年5月至2024年5月期间诊断为PE的女性进行TP检测。结果95例女性TP阳性19例(20%),其中抗磷脂综合征9例(47%),PT G20210A杂合6例(32%),ADAMTS13缺乏2例(11%),PS缺乏1例(5%),FV Leiden杂合1例(5%)。在多因素分析中,宫内生长迟缓(IUGR);优势比(OR) 0.08, 95%可信区间(CI) 0.01 ~ 0.55)和既往流产史(OR 0.22, 95%CI 0.06 ~ 0.96)与TP呈负相关。同时具有上述两种特征、一种特征或一种特征均不具有的女性,其TP患病率分别为0%、15%和32%。TP患病率越高,胎盘功能不全和早产的发生率越低(P
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predicting Thrombophilia in Preeclampsia: Is Universal Testing Necessary?

IntroductionThrombophilia (TP) has been proposed as a potential contributor to preeclampsia (PE). However, there is not a clear consensus on testing PE patients for TP due to contradictory evidences on this association. This study aims to identify what conditions of women with PE are associated with acquired and hereditary TP, and, additionally, to build a model of TP probability using these characteristics.Material and MethodsRetrospective unicentric analysis of women diagnosed with PE referred for TP testing between May 2019 and May 2024.ResultsIn 95 women, 19 (20%) tested positive for TP, of which nine (47%) had antiphospholipid syndrome (APS), six (32%) were heterozygous for PT G20210A, two (11%) had ADAMTS13 deficiency, one (5%) had PS deficiency and one (5%) had heterozygous FV Leiden. In multivariate analysis, intrauterine growth retardation (IUGR; odds ratio (OR) 0.08, 95% confidence interval (CI) 0.01-0.55) and history of previous abortions (OR 0.22, 95%CI 0.06-0.96) were negatively associated with TP. The group of women with both, one or none of those traits showed respectively a TP prevalence of 0%, 15% and 32%. The higher the prevalence of TP, the lower the incidence of placental insufficiency and prematurity (P < .05).ConclusionsIn pregnant women with PE, a history of previous abortions and IUGR were independently associated with the absence of TP. Women without these characteristics would probably benefit most from a Hematology consultation that includes a TP screening. A multinational standard TP screening framework for future studies is warranted to further our understanding of the role of TP in PE and to identify risk-groups for testing.

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来源期刊
CiteScore
4.40
自引率
3.40%
发文量
150
审稿时长
2 months
期刊介绍: CATH is a peer-reviewed bi-monthly journal that addresses the practical clinical and laboratory issues involved in managing bleeding and clotting disorders, especially those related to thrombosis, hemostasis, and vascular disorders. CATH covers clinical trials, studies on etiology, pathophysiology, diagnosis and treatment of thrombohemorrhagic disorders.
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