{"title":"黄魔芋对硫乙酰胺致大鼠肝硬化的急性毒性及肝保护作用。","authors":"Riyadh Zainadin Mawlood, Kamaran Abdoulrahman","doi":"10.2478/acph-2025-0007","DOIUrl":null,"url":null,"abstract":"<p><p><i>Arum maculatum</i> is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate the hepatoprotective impacts of ethanolic extract of the <i>A. maculatum</i> leaves on cirrhosis induced by thioacetamide (TAA) in Sprague--Dawley rats. The rats were treated for two months with thioacetamide (TAA) administered intraperitoneally thrice weekly. Histopathological examination revealed severe liver damage in the thioacetamide control group, while the silymarin treatments (<i>p</i> < 0.05). Furthermore, <i>A. maculatum</i> treatment led to the normalization of pro-inflammatory cytokines TNF-α and IL-6, and increased expression of the anti-inflammatory cytokine IL-10 (<i>p</i> < 0.05). Thus, <i>A. maculatum</i> leaves might have a hepatoprotective role in rat liver cirrhosis induced by TAA, along with antioxidant and anti-inflammatory effects.</p>","PeriodicalId":7034,"journal":{"name":"Acta Pharmaceutica","volume":"75 1","pages":"87-102"},"PeriodicalIF":2.1000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Acute toxicity and hepatoprotective effect of <i>Arum maculatum</i> on rat liver cirrhosis induced with thioacetamide.\",\"authors\":\"Riyadh Zainadin Mawlood, Kamaran Abdoulrahman\",\"doi\":\"10.2478/acph-2025-0007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Arum maculatum</i> is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate the hepatoprotective impacts of ethanolic extract of the <i>A. maculatum</i> leaves on cirrhosis induced by thioacetamide (TAA) in Sprague--Dawley rats. The rats were treated for two months with thioacetamide (TAA) administered intraperitoneally thrice weekly. Histopathological examination revealed severe liver damage in the thioacetamide control group, while the silymarin treatments (<i>p</i> < 0.05). Furthermore, <i>A. maculatum</i> treatment led to the normalization of pro-inflammatory cytokines TNF-α and IL-6, and increased expression of the anti-inflammatory cytokine IL-10 (<i>p</i> < 0.05). Thus, <i>A. maculatum</i> leaves might have a hepatoprotective role in rat liver cirrhosis induced by TAA, along with antioxidant and anti-inflammatory effects.</p>\",\"PeriodicalId\":7034,\"journal\":{\"name\":\"Acta Pharmaceutica\",\"volume\":\"75 1\",\"pages\":\"87-102\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Pharmaceutica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2478/acph-2025-0007\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Pharmaceutica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/acph-2025-0007","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"Print","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Acute toxicity and hepatoprotective effect of Arum maculatum on rat liver cirrhosis induced with thioacetamide.
Arum maculatum is a medicinal plant that has been employed in traditional medicine for treating liver diseases. The objective of the current study was to evaluate the hepatoprotective impacts of ethanolic extract of the A. maculatum leaves on cirrhosis induced by thioacetamide (TAA) in Sprague--Dawley rats. The rats were treated for two months with thioacetamide (TAA) administered intraperitoneally thrice weekly. Histopathological examination revealed severe liver damage in the thioacetamide control group, while the silymarin treatments (p < 0.05). Furthermore, A. maculatum treatment led to the normalization of pro-inflammatory cytokines TNF-α and IL-6, and increased expression of the anti-inflammatory cytokine IL-10 (p < 0.05). Thus, A. maculatum leaves might have a hepatoprotective role in rat liver cirrhosis induced by TAA, along with antioxidant and anti-inflammatory effects.
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AP is an international, multidisciplinary journal devoted to pharmaceutical and allied sciences and contains articles predominantly on core biomedical and health subjects. The aim of AP is to increase the impact of pharmaceutical research in academia, industry and laboratories. With strong emphasis on quality and originality, AP publishes reports from the discovery of a drug up to clinical practice. Topics covered are: analytics, biochemistry, biopharmaceutics, biotechnology, cell biology, cell cultures, clinical pharmacy, drug design, drug delivery, drug disposition, drug stability, gene technology, medicine (including diagnostics and therapy), medicinal chemistry, metabolism, molecular modeling, pharmacology (clinical and animal), peptide and protein chemistry, pharmacognosy, pharmacoepidemiology, pharmacoeconomics, pharmacodynamics and pharmacokinetics, protein design, radiopharmaceuticals, and toxicology.
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