Epstein-Barr病毒重塑肿瘤微环境:从原发部位到远处转移生态位

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Qiuyun Li, Yuping Liu, Yong Chen, Yujuan Huang, Yayan Deng, Qianqing Fan, Lihong Huang, Xue Liu, Jiaxiang Ye, Yongqiang Li, Jiazhang Wei, Jinyan Zhang
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引用次数: 0

摘要

eb病毒(EBV)是世界范围内最普遍的病毒之一,EBV感染与多种淋巴和上皮肿瘤有着千丝万缕的联系。EBV通过改变肿瘤微环境(TME)来促进恶性疾病的发展,TME是一个复杂而不断发展的系统,促进肿瘤的生长、侵袭和转移。EBV感染对构成TME的细胞和非细胞成分有深远的影响。我们的综述总结了ebv重塑的TME的组成,特别关注ebv诱导的非肿瘤细胞的功能表型。此外,我们讨论了逆转EBV驱动的TME重塑作为治疗EBV感染相关恶性肿瘤的治疗策略的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Tumor Microenvironment Remodeled by Epstein-Barr Virus: From Primary Site to Distant Metastatic Niche.

Epstein-Barr virus (EBV) is one of the most pervasive viruses worldwide, and EBV infection is inextricably linked to a multitude of lymphoid and epithelial neoplasms. EBV is responsible for the advancement of malignant disease by modifying the tumor microenvironment (TME), which is a sophisticated and evolving system that facilitates tumor growth, invasion, and metastasis. EBV infection has a profound impact on the cellular and noncellular components that constitute the TME. Our review presents a summary of the composition of the EBV-remodeled TME, with a particular focus on EBV-induced functional phenotypes in non-tumor cells. Furthermore, we discuss the potential for reversing EBV-driven TME remodeling as a therapeutic strategy for treating the malignancies associated with EBV infection.

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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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