大鼠肠道微生物群中甲基化硒代谢物的营养有效性,二甲基二硒化物和二甲基硒化物。

IF 1.7 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Kazuaki Takahashi, Sayano Iijima, Yasumitsu Ogra
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引用次数: 0

摘要

硒(Se)是动物必需的微量营养素。自然界中存在着各种化学形式的硒,每一种都有不同的生理、营养和毒理学特性。在这项研究中,我们旨在确定二甲基二硒化物(DMDSe,一种单甲基化硒(MMSe)化合物)和二甲基硒化物(DMSe,一种二甲基化硒化合物)这两种已知的肠道细菌代谢物是否可以作为大鼠的硒源。DMDSe可用于硒蛋白的生物合成,并被代谢为尿硒代谢产物。相比之下,DMSe不用于硒蛋白的生物合成,而是进一步甲基化为三甲基硒离子(TMSe),这是尿硒代谢产物之一。我们的研究结果表明,与MMSe不同,二甲基化硒在大鼠中不容易作为硒源。硒蛋白的生物合成需要硒化物,硒的一种未甲基化形式,在代谢途径中。我们的观察结果支持这样的假设,即去甲基化作为一个可逆的甲基化步骤发生在MMSe上,而不是在二甲基化Se上。这表明第二甲基化步骤对于硒失活至关重要,并在动物的代谢中发挥重要作用,以维持硒的稳态。肠道菌群可以合成DMDSe和DMSe,可能通过甲基化过程参与宿主硒代谢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nutritional Availability of Methylated Selenometabolites in Gut Microbiota, Dimethyldiselenide and Dimethylselenide, in Rats.

Selenium (Se) is an essential micronutrient for animals. Various chemical forms of Se exist in nature, each with distinct physiological, nutritional, and toxicological properties. In this study, we aimed to determine whether dimethyldiselenide (DMDSe, a monomethylated Se (MMSe) compound) and dimethylselenide (DMSe, a dimethylated Se compound), known gut bacterial metabolites, could serve as Se sources in rats. DMDSe could be utilized for selenoprotein biosynthesis and was metabolized into urinary selenometabolites. By contrast, DMSe was not utilized for selenoprotein biosynthesis but was further methylated to trimethylselenonium ion (TMSe), one of the urinary Se metabolites. Our findings indicate that dimethylated Se is not readily available as an Se source in rats, unlike MMSe. Selenoprotein biosynthesis requires selenide, an unmethylated form of Se, in the metabolic pathway. Our observations support the hypothesis that demethylation occurs on MMSe as a reversible methylation step but not on dimethylated Se. This suggests that the second methylation step is crucial for inactivating Se and plays a significant role in metabolism to maintain Se homeostasis in animals. Gut microbiota, which can synthesize both DMDSe and DMSe, may contribute to host Se metabolism through methylation processes.

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来源期刊
CiteScore
3.50
自引率
5.00%
发文量
247
审稿时长
2 months
期刊介绍: Biological and Pharmaceutical Bulletin (Biol. Pharm. Bull.) began publication in 1978 as the Journal of Pharmacobio-Dynamics. It covers various biological topics in the pharmaceutical and health sciences. A fourth Society journal, the Journal of Health Science, was merged with Biol. Pharm. Bull. in 2012. The main aim of the Society’s journals is to advance the pharmaceutical sciences with research reports, information exchange, and high-quality discussion. The average review time for articles submitted to the journals is around one month for first decision. The complete texts of all of the Society’s journals can be freely accessed through J-STAGE. The Society’s editorial committee hopes that the content of its journals will be useful to your research, and also invites you to submit your own work to the journals.
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