2024年乌干达西部波特尔堡恶性疟原虫Kelch-13青蒿素部分耐药标记

IF 4.1 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-06-04 Epub Date: 2025-04-23 DOI:10.1128/aac.01755-24

Welmoed van Loon, Emma Schallenberg, Emmanuel Mande, Patrick Musinguzi, Paul Ngobi, Sharon Atukunda, John Rubaihayo, Frank P Mockenhaupt

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引用次数: 0

摘要

在乌干达的Fort Portal，恶性疟原虫Kelch13 （n = 126）存在与青蒿素耐药相关的突变，占4.8% （675V、561H和441L）。9.5%发生了相关性未知的突变490T。PfMDR1变异表明增加了氟芳汀耐受性（N86, 100%）。突变500N缺失，突变199S占12.8%。后者是未知的相关性。这些数据表明，在卢旺达和乌干达耐药热点之间的关键地点以及几乎未受影响的刚果民主共和国，出现了青蒿素耐药性。

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Plasmodium falciparum Kelch-13 artemisinin partial resistance markers in Fort Portal, Western Uganda, 2024.

In Fort Portal, Uganda, artemisinin resistance-associated mutations in Plasmodium falciparum Kelch13 (n = 126) were present in 4.8% (675V, 561H, and 441L). A mutation of unknown relevance, 490T, occurred in 9.5%. PfMDR1 variants suggested increased lumefantrine tolerance (N86, 100%). Mutation 500N was absent, and 199S occurred in 12.8%. The latter is of unknown relevance. These data indicate an incipient emergence of artemisinin resistance in a crucial location between Rwandan and Ugandan resistance hotspots and hardly affected DR Congo.

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.