Yun-Gyoo Lee, Dayeon Seo, Hyun-Il Gil, Hyunjoo Lee, Young Hwan Kim, Heerim Nam, Soo-Youn Ham, Du-Young Kang
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引用次数: 0
摘要
背景：不吸烟者的肺癌是一个日益严重的问题，特别是在东亚，非吸烟相关的风险因素，如遗传易感性，在那里起着至关重要的作用。本研究调查了不吸烟者中肺癌家族史（FHLC）与肺癌风险的关系，并确定这些风险何时增加。方法：这项前瞻性队列研究使用了来自江北三星队列研究的数据，该研究涉及357322名韩国成年人，他们在2011年至2021年期间接受了健康筛查。有吸烟史或既往癌症诊断的167,883人被排除在本研究之外。通过问卷评估FHLC，通过韩国国家癌症发病率数据库确定肺癌发病率。结果：在189,439名研究人群中，11,678人报告了fhplc。25例（0.21%）FHLC患者和148例（0.083%）非FHLC患者发生肺癌，未调整的风险比（HR）为1.76（95%可信区间[CI]: 1.15-2.69, P = 0.009）。在调整性别、体重指数、饮酒、运动和病史后，FHLC仍然是显著的危险因素（HR: 1.93, 95% CI: 1.24-3.01, P = 0.004）。基于fhcc的肺癌发生风险在45岁后出现显著差异。倾向评分匹配证实，非吸烟者中有FHLC的人比没有FHLC的人患肺癌的风险更高。结论：从不吸烟的FHLC患者患肺癌的风险显著增加，其风险在45岁后开始增加。将fhplc整合到肺癌筛查模型中有可能提高早期发现。
Assessment of Lung Cancer Risks Related to Family History in Never-Smokers: A Cohort Study.
Background: Lung cancer in never-smokers is an increasing issue, particularly in East Asia, where nonsmoking-related risk factors, such as genetic predispositions, play a crucial role. This study investigated the association of family history of lung cancer (FHLC) with lung cancer risk among never-smokers and identified when these risks increased.
Methods: This prospective cohort study used data from the Kangbuk Samsung Cohort Study, which involved 357,322 Korean adults who underwent health screenings from 2011 to 2021. The 167,883 with a history of smoking or previous cancer diagnoses were excluded from this study. FHLC was evaluated through questionnaires, and incident lung cancer cases were determined through the Korea National Cancer Incidence Database.
Results: Of the 189,439 study population, 11,678 reported FHLC. Incident lung cancer was observed in 25 (0.21%) participants with FHLC and 148 (0.083%) without FHLC, yielding an unadjusted hazard ratio (HR) of 1.76 (95% confidence interval [CI]: 1.15-2.69, P = .009). FHLC remained a significant risk factor after adjusting for sex, body mass index, alcohol consumption, exercise, and medical history (HR: 1.93, 95% CI: 1.24-3.01, P = .004). The risk of incident lung cancer based on FHLC significantly diverged after 45 years of age. Propensity score matching confirmed a higher lung cancer risk in nonsmokers with FHLC compared with those without FHLC.
Conclusions: Never-smokers with FHLC demonstrated a significantly higher risk of developing lung cancer, which risks start to increase after 45 years of age. Integrating FHLC into lung cancer screening models has the potential to enhance early detection.
期刊介绍：
Clinical Lung Cancer is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lung cancer. Clinical Lung Cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. The main emphasis is on recent scientific developments in all areas related to lung cancer. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.
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