单克隆抗体在肿瘤治疗中的应用综述

IF 3 Q3 IMMUNOLOGY

Antibodies Pub Date : 2025-04-11 DOI:10.3390/antib14020035

Angel Justiz-Vaillant, Bijay Raj Pandit, Chandrashekhar Unakal, Sehlule Vuma, Patrick Eberechi Akpaka

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引用次数: 0

摘要

单克隆抗体（mab）靶向癌症治疗的各种途径在增强免疫系统识别和消除肿瘤细胞的能力方面发挥着至关重要的作用。这些疗法被设计为阻断抑制性免疫检查点途径或针对特定的肿瘤细胞标记物进行直接破坏。此外，单克隆抗体可以调节肿瘤微环境，增强抗体依赖性细胞毒性，抑制血管生成，进一步扩大其治疗作用。下面是针对关键途径的单克隆抗体的总结，以及它们的适应症和作用机制，并根据治疗机制进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Comprehensive Review About the Use of Monoclonal Antibodies in Cancer Therapy.

Monoclonal antibodies (mAbs) targeting various pathways in cancer therapy play crucial roles in enhancing the immune system's ability to recognise and eliminate tumour cells. These therapies are designed to either block inhibitory immune checkpoint pathways or to target specific tumour cell markers for direct destruction. Additionally, mAbs can modulate the tumour microenvironment, enhance antibody-dependent cellular cytotoxicity, and inhibit angiogenesis, further amplifying their therapeutic impact. Below is a summary of monoclonal antibodies targeting key pathways, along with their indications and mechanisms of action, which are reviewed based on therapeutic mechanisms.

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来源期刊

Antibodies IMMUNOLOGY-

CiteScore

7.10

自引率

6.40%

发文量

审稿时长

11 weeks

期刊介绍： Antibodies (ISSN 2073-4468), an international, peer-reviewed open access journal which provides an advanced forum for studies related to antibodies and antigens. It publishes reviews, research articles, communications and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided. Electronic files or software regarding the full details of the calculation and experimental procedure - if unable to be published in a normal way - can be deposited as supplementary material. This journal covers all topics related to antibodies and antigens, topics of interest include (but are not limited to): antibody-producing cells (including B cells), antibody structure and function, antibody-antigen interactions, Fc receptors, antibody manufacturing antibody engineering, antibody therapy, immunoassays, antibody diagnosis, tissue antigens, exogenous antigens, endogenous antigens, autoantigens, monoclonal antibodies, natural antibodies, humoral immune responses, immunoregulatory molecules.