总是在移动：核过程中的染色质动力学概述。

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry Biochemistry Pub Date : 2025-05-20 Epub Date: 2025-05-01 DOI:10.1021/acs.biochem.5c00114

Charlotte M Delvaux de Fenffe, Jolijn Govers, Francesca Mattiroli

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引用次数: 0

摘要

我们的基因组由染色质组成，染色质是一种由核小体组成的动态模块化结构。染色质组织控制对DNA序列的访问，在细胞身份和功能中起着基本作用。核小体如何使这些过程成为可能是一个活跃的研究领域。本文综述了染色质动力学及其性质、机制和功能的研究进展。我们强调了在转录、DNA复制和修复过程中染色质动力学控制的不同方式。最近的技术发展促进了这一领域的发现，我们对未来的研究方向进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes.

Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and function. How nucleosomes enable these processes is an active area of study. In this review, we provide an overview of chromatin dynamics, its properties, mechanisms, and functions. We highlight the diverse ways by which chromatin dynamics is controlled during transcription, DNA replication, and repair. Recent technological developments have promoted discoveries in this area, to which we provide an outlook on future research directions.

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来源期刊

Biochemistry Biochemistry 生物-生化与分子生物学

CiteScore

5.50

自引率

3.40%

发文量

336

审稿时长

1-2 weeks

期刊介绍： Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.