{"title":"淋巴系统功能在管理癌症和有意义的生活（CALM）干预以改善乳腺癌幸存者化疗相关认知障碍（CRCI）中的作用","authors":"Chen Gan, Ling Cheng, Senbang Yao, Longyu Hu, Xinyi Zheng, Meiwen Ling, Jian Xu, Mingjun Zhang, Huaidong Cheng","doi":"10.62347/YWYC9782","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study employed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to investigate the glymphatic system's involvement in Managing Cancer and Living Meaningfully (CALM) intervention to improve chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCs).</p><p><strong>Methods: </strong>68 BCs were randomly assigned to the CALM (34 patients) or care-as-usual (CAU) (34 patients) groups. The Mini-Mental State Examination (MMSE) and Prospective and Retrospective Memory Questionnaire (PRMQ) were calculated for all patients before and after the intervention. Imaging data were collected from the CALM group to analyze the DTI-ALPS index before and after the intervention.</p><p><strong>Results: </strong>The CALM group showed significant improvements than the CAU group in MMSE (F = 6.612; <i>P</i> = 0.012), retrospective memory (RM) (F = 5.154; <i>P</i> = 0.027), and prospective memory (PM) (F = 8.731; <i>P</i> = 0.004) scores after the intervention. A significantly increased in the DTI-ALPS index was observed following CALM intervention compared to baseline (<i>t</i> = -2.111; <i>P</i> = 0.042). The ∆DTI-ALPS index was correlated with both ΔMMSE (<i>P</i> = 0.027, <i>r</i> = 0.378) and ∆RM (<i>P</i> = 0.026, <i>r</i> = -0.381) scores.</p><p><strong>Conclusion: </strong>CALM intervention improved CRCI and glymphatic function in BCs,with observed correlations between these enhancements.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 3","pages":"1148-1157"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982742/pdf/","citationCount":"0","resultStr":"{\"title\":\"The role of glymphatic system function in the managing Cancer and Living Meaningfully (CALM) intervention to improve chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors.\",\"authors\":\"Chen Gan, Ling Cheng, Senbang Yao, Longyu Hu, Xinyi Zheng, Meiwen Ling, Jian Xu, Mingjun Zhang, Huaidong Cheng\",\"doi\":\"10.62347/YWYC9782\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study employed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to investigate the glymphatic system's involvement in Managing Cancer and Living Meaningfully (CALM) intervention to improve chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCs).</p><p><strong>Methods: </strong>68 BCs were randomly assigned to the CALM (34 patients) or care-as-usual (CAU) (34 patients) groups. The Mini-Mental State Examination (MMSE) and Prospective and Retrospective Memory Questionnaire (PRMQ) were calculated for all patients before and after the intervention. Imaging data were collected from the CALM group to analyze the DTI-ALPS index before and after the intervention.</p><p><strong>Results: </strong>The CALM group showed significant improvements than the CAU group in MMSE (F = 6.612; <i>P</i> = 0.012), retrospective memory (RM) (F = 5.154; <i>P</i> = 0.027), and prospective memory (PM) (F = 8.731; <i>P</i> = 0.004) scores after the intervention. A significantly increased in the DTI-ALPS index was observed following CALM intervention compared to baseline (<i>t</i> = -2.111; <i>P</i> = 0.042). The ∆DTI-ALPS index was correlated with both ΔMMSE (<i>P</i> = 0.027, <i>r</i> = 0.378) and ∆RM (<i>P</i> = 0.026, <i>r</i> = -0.381) scores.</p><p><strong>Conclusion: </strong>CALM intervention improved CRCI and glymphatic function in BCs,with observed correlations between these enhancements.</p>\",\"PeriodicalId\":7437,\"journal\":{\"name\":\"American journal of cancer research\",\"volume\":\"15 3\",\"pages\":\"1148-1157\"},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2025-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11982742/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of cancer research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.62347/YWYC9782\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/YWYC9782","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
The role of glymphatic system function in the managing Cancer and Living Meaningfully (CALM) intervention to improve chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors.
Objective: This study employed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index to investigate the glymphatic system's involvement in Managing Cancer and Living Meaningfully (CALM) intervention to improve chemotherapy-related cognitive impairment (CRCI) in breast cancer survivors (BCs).
Methods: 68 BCs were randomly assigned to the CALM (34 patients) or care-as-usual (CAU) (34 patients) groups. The Mini-Mental State Examination (MMSE) and Prospective and Retrospective Memory Questionnaire (PRMQ) were calculated for all patients before and after the intervention. Imaging data were collected from the CALM group to analyze the DTI-ALPS index before and after the intervention.
Results: The CALM group showed significant improvements than the CAU group in MMSE (F = 6.612; P = 0.012), retrospective memory (RM) (F = 5.154; P = 0.027), and prospective memory (PM) (F = 8.731; P = 0.004) scores after the intervention. A significantly increased in the DTI-ALPS index was observed following CALM intervention compared to baseline (t = -2.111; P = 0.042). The ∆DTI-ALPS index was correlated with both ΔMMSE (P = 0.027, r = 0.378) and ∆RM (P = 0.026, r = -0.381) scores.
Conclusion: CALM intervention improved CRCI and glymphatic function in BCs,with observed correlations between these enhancements.
期刊介绍：
The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.
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