Mehdi Liaghat , Mohammad Abbaszadeh , Sasan Sadrizadeh , Omid Abouali
{"title":"双向相互作用假设对鼻腔喷雾模拟影响的实验与数值研究","authors":"Mehdi Liaghat , Mohammad Abbaszadeh , Sasan Sadrizadeh , Omid Abouali","doi":"10.1016/j.euromechflu.2025.204258","DOIUrl":null,"url":null,"abstract":"<div><div>Using nasal sprays as a drug delivery method to the nasal cavity is widespread due to their convenience and effectiveness in treating various conditions. The high velocity of droplets exiting the nozzle can significantly impact the flow field, leading to changes in deposition patterns. Therefore, it is crucial to understand the interactions between the droplets and the fluid. In this research, we propose an innovative and cost-effective approach to investigate the two-way interactions between droplets and the fluid in numerical simulations of nasal sprays. We employ ultra-high-speed photography using an infinitesimal light pulse to examine spray puffs and extract droplet characteristics. We aim to determine whether the two-way interaction assumption produces significant differences in a numerical model. We first measured the droplet size distribution and spray cone angle in unconfined ambient conditions to achieve the objective. We then extended the measurement to real-sized 3D printed models of the nasal passage truncated in various sections to analyze how droplet deposition occurs in different nasal locations. We also conducted transient numerical simulations based on the measured data to investigate the importance of two-way interactions assumption. The results of the numerical simulations were then compared to the experimental results. Comparing the experimental and numerical results demonstrated that the two-way interaction assumption produced significant differences, indicating that it must be considered while modeling the nasal spray. Overall, this research's findings can significantly contribute to optimizing the design of nasal sprays and enhancing the effectiveness of drug delivery to the targeted location.</div></div>","PeriodicalId":11985,"journal":{"name":"European Journal of Mechanics B-fluids","volume":"113 ","pages":"Article 204258"},"PeriodicalIF":2.5000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experimental and numerical investigations on the impact of two-way interaction assumption in the nasal spray simulations\",\"authors\":\"Mehdi Liaghat , Mohammad Abbaszadeh , Sasan Sadrizadeh , Omid Abouali\",\"doi\":\"10.1016/j.euromechflu.2025.204258\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Using nasal sprays as a drug delivery method to the nasal cavity is widespread due to their convenience and effectiveness in treating various conditions. The high velocity of droplets exiting the nozzle can significantly impact the flow field, leading to changes in deposition patterns. Therefore, it is crucial to understand the interactions between the droplets and the fluid. In this research, we propose an innovative and cost-effective approach to investigate the two-way interactions between droplets and the fluid in numerical simulations of nasal sprays. We employ ultra-high-speed photography using an infinitesimal light pulse to examine spray puffs and extract droplet characteristics. We aim to determine whether the two-way interaction assumption produces significant differences in a numerical model. We first measured the droplet size distribution and spray cone angle in unconfined ambient conditions to achieve the objective. We then extended the measurement to real-sized 3D printed models of the nasal passage truncated in various sections to analyze how droplet deposition occurs in different nasal locations. We also conducted transient numerical simulations based on the measured data to investigate the importance of two-way interactions assumption. The results of the numerical simulations were then compared to the experimental results. Comparing the experimental and numerical results demonstrated that the two-way interaction assumption produced significant differences, indicating that it must be considered while modeling the nasal spray. Overall, this research's findings can significantly contribute to optimizing the design of nasal sprays and enhancing the effectiveness of drug delivery to the targeted location.</div></div>\",\"PeriodicalId\":11985,\"journal\":{\"name\":\"European Journal of Mechanics B-fluids\",\"volume\":\"113 \",\"pages\":\"Article 204258\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-02-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Mechanics B-fluids\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0997754625000329\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MECHANICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Mechanics B-fluids","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0997754625000329","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MECHANICS","Score":null,"Total":0}
Experimental and numerical investigations on the impact of two-way interaction assumption in the nasal spray simulations
Using nasal sprays as a drug delivery method to the nasal cavity is widespread due to their convenience and effectiveness in treating various conditions. The high velocity of droplets exiting the nozzle can significantly impact the flow field, leading to changes in deposition patterns. Therefore, it is crucial to understand the interactions between the droplets and the fluid. In this research, we propose an innovative and cost-effective approach to investigate the two-way interactions between droplets and the fluid in numerical simulations of nasal sprays. We employ ultra-high-speed photography using an infinitesimal light pulse to examine spray puffs and extract droplet characteristics. We aim to determine whether the two-way interaction assumption produces significant differences in a numerical model. We first measured the droplet size distribution and spray cone angle in unconfined ambient conditions to achieve the objective. We then extended the measurement to real-sized 3D printed models of the nasal passage truncated in various sections to analyze how droplet deposition occurs in different nasal locations. We also conducted transient numerical simulations based on the measured data to investigate the importance of two-way interactions assumption. The results of the numerical simulations were then compared to the experimental results. Comparing the experimental and numerical results demonstrated that the two-way interaction assumption produced significant differences, indicating that it must be considered while modeling the nasal spray. Overall, this research's findings can significantly contribute to optimizing the design of nasal sprays and enhancing the effectiveness of drug delivery to the targeted location.
期刊介绍:
The European Journal of Mechanics - B/Fluids publishes papers in all fields of fluid mechanics. Although investigations in well-established areas are within the scope of the journal, recent developments and innovative ideas are particularly welcome. Theoretical, computational and experimental papers are equally welcome. Mathematical methods, be they deterministic or stochastic, analytical or numerical, will be accepted provided they serve to clarify some identifiable problems in fluid mechanics, and provided the significance of results is explained. Similarly, experimental papers must add physical insight in to the understanding of fluid mechanics.