基于n -氧化物的荧光探针通过选择性氧化亚铁离子抑制铁下垂

IF 7.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chemical Science Pub Date : 2025-05-14 DOI:10.1039/d4sc07972h

Kanta Kawai, Rie Haruki, Shunsuke Nozawa, Hideko Nagasawa, Tasuku Hirayama

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引用次数: 0

摘要

铁死亡是一种铁依赖性程序性细胞死亡，与多种疾病和生理过程有关。尽管有各种铁下垂诱导剂，但铁下垂的治疗选择仍然局限于铁螯合剂和自由基清除剂。本研究表明，我们实验室开发的铁（II）选择性荧光探针可以通过选择性氧化铁（II）作为铁下垂抑制剂，这是脂质过氧化所必需的。这一发现提供了一类新的铁下垂抑制剂作为潜在的治疗应用。

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Inhibition of ferroptosis by N-oxide-based fluorescent probes via selective oxidation of ferrous ion

Ferroptosis, a form of iron-dependent programmed cell death, is linked to various diseases and physiological processes. Despite the availability of various ferroptosis inducers, the therapeutic options for ferroptosis remain limited to iron chelators and radical scavengers. This study demonstrates that Fe(II)-selective fluorescent probes developed in our lab could serve as ferroptosis inhibitors via selective oxidation of Fe(II), which is required for lipid peroxidation. This finding provides a new class of ferroptosis inhibitors as potential therapeutic applications.

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来源期刊

Chemical Science CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

4.80%

发文量

1352

审稿时长

2.1 months

期刊介绍： Chemical Science is a journal that encompasses various disciplines within the chemical sciences. Its scope includes publishing ground-breaking research with significant implications for its respective field, as well as appealing to a wider audience in related areas. To be considered for publication, articles must showcase innovative and original advances in their field of study and be presented in a manner that is understandable to scientists from diverse backgrounds. However, the journal generally does not publish highly specialized research.