pd催化4-戊烯酸三组分1,1-碳胺化反应。

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-13 DOI:10.1021/acs.orglett.5c00990

Lihua Mao,Xiangwen Tan,Jiahao Wu,Wanqing Wu,Huanfeng Jiang

引用次数: 0

摘要

本文描述了一种钯催化4-戊烯酸三组分1,1-碳胺化的方法，成功构建了δ-内酰胺衍生物。该方案具有良好的1,1-区域选择性，高台阶经济性和原子经济性以及良好的官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pd-Catalyzed Three-Component 1,1-Carboamination of 4-Pentenoic Acid.

Herein, we describe a method to achieve the three-component 1,1-carboamination of 4-pentenoic acid by palladium catalysis, successfully constructing δ-lactam derivatives. The protocol features excellent 1,1-regioselectivity, high step and atom economy, and good functional group tolerance.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.