儿童血清3型相关侵袭性肺炎球菌疾病：澳大利亚15年国家监测数据分析

IF 9 1区医学 Q1 RESPIRATORY SYSTEM

Thorax Pub Date : 2025-05-13 DOI:10.1136/thorax-2025-223125

Nusrat Homaira,Jahidur Rahman Khan,Adam Jaffé

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引用次数: 0

摘要

2011年，13价结合肺炎球菌疫苗（13vPCV）取代了澳大利亚免疫计划中的7vPCV，成为3+0计划，2018年更新为2+1计划。我们分析了国家监测数据，以调查学龄前儿童肺炎球菌血清3型（ST3）侵袭性肺炎球菌病（IPD）发病率的变化。2009-2023年，ST3型IPD /10万儿童的发病率从2009年的0.42上升到2023年的3.65。与2009-2011年（7vPCv）相比，2012-2018年（13vPCV 3+0剂量）的ST3 IPD发病率几乎是2012-2018年（13vPCV 2+1剂量）的4倍，2019-2023年（13vPCV 2+1剂量）的2倍，表明对ST3的保护有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Serotype 3 associated invasive pneumococcal disease in children: analysis of 15 years of Australian national surveillance data.

The 13-valent conjugate pneumococcal vaccine (13vPCV) replaced the 7vPCV in the Australian Immunisation Program in 2011 as a 3+0 schedule, updated to 2+1 schedule in 2018. We analysed national surveillance data to investigate the change in the incidence of pneumococcal serotype 3 (ST3) invasive pneumococcal disease (IPD) in preschool children. During 2009-2023 the incidence/100 000 children of ST3 IPD increased from 0.42 in 2009 to 3.65 in 2023. Compared with 2009-2011 (7vPCv), ST3 IPD incidence in 2012-2018 (13vPCV 3+0 dose) was almost four times higher and two times higher in 2019-2023 (13vPCV 2+1 dose) compared with 2012-2018 suggesting limited protection against ST3.

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来源期刊

Thorax 医学-呼吸系统

CiteScore

16.10

自引率

2.00%

发文量

197

审稿时长

1 months

期刊介绍： Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.