Hyaluronic acid modified magnetic nanoparticles decorated silver nanoparticles: catalytic application in C-S coupling and investigation of its anti-inflammatory, analgesic and anaesthetic activities

The current research deals with the synthesis and characteristic depiction of Ag NPs withheld and hyaluronic acid (HA) adjusted Fe₃O₄ nanoparticles (Fe₃O₄@HA/Ag NPs) observing a bio-promoted by law requiring no involvement toxic and deleterious reducers or reactants. A variety of physicochemical methodological analysis, including FT-IR, FE-SEM, TEM, EDX, XRD, VSM, and ICP-OES, contributed to identify and investigate the conceptual and various functional dimensions.We also applied the Fe₃O₄@HA/Ag NPs as the efficient catalyst for C-S coupling reactions to achieve the related aromatic sulfides. The catalyst shown excellent recyclability for 8 runs without significant performance loss.The Fe₃O₄@HA/Ag NPs nanocomposite was subsequently explored towards the anaesthetic, analgesic and anti-inflammatory activities. The nanocomposite Fe₃O₄@HA/Ag NPs exhibited an IC₅₀ value of 56 µg/mL against DPPH free radicals.The local anesthetic effects were assessed in models of frogs and guinea pigs, revealing noteworthy efficacy in both animal species.The analgesic effects were evaluated in mice by administering various doses orally.Writhing episodes caused by acetic acid were notably decreased in a manner that depended on the dosage.Furthermore, an assessment was conducted to determine the anti-inflammatory effects of the identical dosage.After being administered orally, the inflammation in the paws of mice induced by carrageenin, a commonly used inflammatory agent, was noticeably reduced.The Fe₃O₄@HA/Ag NPs nanocomposite shows promise as a groundbreaking therapeutic medication in the future, demonstrating analgesic, antioxidant properties, anti-inflammatory effects, and local anesthetic qualities.