基于copula的生存数据非正态变换线性模型

IF 0.8 4区 数学 Q3 STATISTICS & PROBABILITY
Huazhen Yu , Lixin Zhang
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引用次数: 0

摘要

虽然独立审查假设是生存分析中常用的假设,但是当审查时间与生存时间相关时,独立审查假设就会被违反,这种情况在许多实际应用中经常发生。为了解决这个问题,我们提出了一种灵活的半参数方法。我们的方法包括用一个联合变换的线性模型拟合生存时间和审查时间,其中变换的函数是未指定的。这允许一个非常一般的模型类别,可以解释可能的协变量效应,同时也适应行政审查。我们假设变换后的变量具有基于参数copula和参数边际的二元非正态分布,这进一步增强了方法的灵活性。我们证明了模型的可辨识性,并在适当的正则性条件和假设下,建立了模型参数的一致性和渐近正态性。此外,我们通过大量的仿真研究来评估我们的方法的性能,并提供了一个真实的数据示例来说明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Copula-based semiparametric nonnormal transformed linear model for survival data with dependent censoring
Although the independent censoring assumption is commonly used in survival analysis, it can be violated when the censoring time is related to the survival time, which often happens in many practical applications. To address this issue, we propose a flexible semiparametric method for dependent censored data. Our approach involves fitting the survival time and the censoring time with a joint transformed linear model, where the transformed function is unspecified. This allows for a very general class of models that can account for possible covariate effects, while also accommodating administrative censoring. We assume that the transformed variables have a bivariate nonnormal distribution based on parametric copulas and parametric marginals, which further enhances the flexibility of our method. We demonstrate the identifiability of the proposed model and establish the consistency and asymptotic normality of the model parameters under appropriate regularity conditions and assumptions. Furthermore, we evaluate the performance of our method through extensive simulation studies, and provide a real data example for illustration.
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来源期刊
Journal of Statistical Planning and Inference
Journal of Statistical Planning and Inference 数学-统计学与概率论
CiteScore
2.10
自引率
11.10%
发文量
78
审稿时长
3-6 weeks
期刊介绍: The Journal of Statistical Planning and Inference offers itself as a multifaceted and all-inclusive bridge between classical aspects of statistics and probability, and the emerging interdisciplinary aspects that have a potential of revolutionizing the subject. While we maintain our traditional strength in statistical inference, design, classical probability, and large sample methods, we also have a far more inclusive and broadened scope to keep up with the new problems that confront us as statisticians, mathematicians, and scientists. We publish high quality articles in all branches of statistics, probability, discrete mathematics, machine learning, and bioinformatics. We also especially welcome well written and up to date review articles on fundamental themes of statistics, probability, machine learning, and general biostatistics. Thoughtful letters to the editors, interesting problems in need of a solution, and short notes carrying an element of elegance or beauty are equally welcome.
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