{"title":"CAR-T细胞——癌症治疗的未来","authors":"Reuben Benjamin, Francesco Restuccia","doi":"10.1016/j.mpmed.2025.03.002","DOIUrl":null,"url":null,"abstract":"<div><div>Chimeric antigen receptor T cells (CAR-T) are a novel form of immunotherapy in which T cells from individuals with cancer are genetically modified to express a chimeric receptor enabling them to target cancer cells, with profound anti-tumour effects. CAR-T cells have shown highly impressive results in the treatment of B cell haematological malignancies, with several CD19-targeted CAR-T cells products now approved for routine clinical use. The main adverse effects of CAR-T cells treatment include cytokine-release syndrome, neurotoxicity and cytopenias; these require prompt treatment in specialist centres. Future developments related to CAR-T cells are likely to see products with improved efficacy, newer indications such as solid tumours and autoimmune disease and more affordable and easier access to this promising therapy.</div></div>","PeriodicalId":74157,"journal":{"name":"Medicine (Abingdon, England : UK ed.)","volume":"53 5","pages":"Pages 340-342"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CAR-T cells – the future for cancer therapy\",\"authors\":\"Reuben Benjamin, Francesco Restuccia\",\"doi\":\"10.1016/j.mpmed.2025.03.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Chimeric antigen receptor T cells (CAR-T) are a novel form of immunotherapy in which T cells from individuals with cancer are genetically modified to express a chimeric receptor enabling them to target cancer cells, with profound anti-tumour effects. CAR-T cells have shown highly impressive results in the treatment of B cell haematological malignancies, with several CD19-targeted CAR-T cells products now approved for routine clinical use. The main adverse effects of CAR-T cells treatment include cytokine-release syndrome, neurotoxicity and cytopenias; these require prompt treatment in specialist centres. Future developments related to CAR-T cells are likely to see products with improved efficacy, newer indications such as solid tumours and autoimmune disease and more affordable and easier access to this promising therapy.</div></div>\",\"PeriodicalId\":74157,\"journal\":{\"name\":\"Medicine (Abingdon, England : UK ed.)\",\"volume\":\"53 5\",\"pages\":\"Pages 340-342\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medicine (Abingdon, England : UK ed.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1357303925000490\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine (Abingdon, England : UK ed.)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1357303925000490","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chimeric antigen receptor T cells (CAR-T) are a novel form of immunotherapy in which T cells from individuals with cancer are genetically modified to express a chimeric receptor enabling them to target cancer cells, with profound anti-tumour effects. CAR-T cells have shown highly impressive results in the treatment of B cell haematological malignancies, with several CD19-targeted CAR-T cells products now approved for routine clinical use. The main adverse effects of CAR-T cells treatment include cytokine-release syndrome, neurotoxicity and cytopenias; these require prompt treatment in specialist centres. Future developments related to CAR-T cells are likely to see products with improved efficacy, newer indications such as solid tumours and autoimmune disease and more affordable and easier access to this promising therapy.
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