化妆品油注射诱导的肉芽肿炎症标志物监测疾病严重程度和进展的价值

IF 3.5 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Bone Pub Date : 2025-04-28 DOI:10.1016/j.bone.2025.117500

Ida Enggaard Kaae , Sam Kafai Yahyavi , Martin Blomberg Jensen , Ebbe Eldrup

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引用次数: 0

摘要

目的美容油注射可引起异物肉芽肿，导致炎症驱动的肾外活性维生素D （1,25(OH)2D3）的产生和严重的高钙血症。本研究探讨了炎症标志物：白细胞介素2受体（IL-2R）、肽基二肽酶（ACE）和铁蛋白在油致肉芽肿患者中的纵向变化。材料与方法109例男性患者根据基线钙水平进行分层。28%为高钙血症，72%为正常钙血症。正常钙血症患者根据血清甲状旁腺激素（PTH）浓度细分为抑制(<；2.0 pmol/L, n = 30)或正常（≥2.0 pmol/L, n = 49）浓度。在48个月内收集血液样本，使用Pearson相关和混合模型分析检查炎症标志物和钙稳态的纵向变化。结果IL-2R、ACE、铁蛋白与血清离子钙浓度呈正相关，IL-2R与血清1,25(OH)2D3呈正相关。在高钙血症患者中，IL-2R在6个月（p = 0.041）、24个月（p = 0.048）和36个月（p = 0.035）时下降。48个月时ACE升高（p = 0.008）。在正常钙血症和抑制PTH的患者中，IL-2R在24个月时升高（p = 0.021），而正常钙血症和PTH正常的患者血清铁蛋白在6个月（p = 0.040）、12个月（p = 0.008）、24个月（p = 0.028）和48个月（p = 0.005）时升高。结论在基线水平上，离子钙浓度与IL-2R、离子钙与铁蛋白、125 （OH）₂D₃与IL-2R呈正相关。高钙血症和PTH抑制与基线时IL-2R和铁蛋白浓度升高有关。随着时间的推移，高钙血症患者IL-2R和铁蛋白浓度下降，一些患者接受免疫调节药物治疗。正常钙血症患者未经治疗时IL-2R和铁蛋白浓度升高。

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Value of inflammatory markers for monitoring disease severity and progression in granuloma induced by cosmetic oil injections

Objective

Cosmetic oil injections can cause foreign body granulomas, leading to inflammation-driven extrarenal production of activated vitamin D (1,25(OH)₂D₃) and severe hypercalcemia. This study investigates longitudinal changes in inflammatory markers: interleukin 2 receptor (IL-2R), peptidyl dipeptidase (ACE), and ferritin in patients with oil-induced granuloma.

Materials and methods

109 male patients were stratified according to baseline calcium status. 28 % had hypercalcemia, and 72 % normocalcemia. Normocalcemic patients were subdivided based on serum parathyroid hormone (PTH) concentrations into suppressed (< 2.0 pmol/L, n = 30) or normal (≥ 2.0 pmol/L, n = 49) concentrations. Blood samples were collected over 48 months and longitudinal changes in inflammatory markers and calcium homeostasis were examined using Pearson correlation and mixed model analyses.

Results

IL-2R, ACE, and ferritin were positively correlated with serum concentration of ionized calcium, while IL-2R was associated with serum 1,25(OH)₂D_3. In patients with hypercalcemia, IL-2R decreased at 6 (p = 0.041), 24 (p = 0.048), and 36 months (p = 0.035). ACE increased at 48 months (p = 0.008). In patients with normocalcemia and suppressed PTH, IL-2R increased at 24 months (p = 0.021), while serum ferritin increased in patients with normocalcemia and normal PTH at 6 (p = 0.040), 12 (p = 0.008), 24 (p = 0.028), and 48 months (p = 0.005).

Conclusions

Positive correlations were observed at baseline between ionized calcium concentrations and IL-2R, ionized calcium and ferritin, and 1,25(OH)₂D₃ and IL-2R. Hypercalcemia and suppressed PTH was associated with elevated IL-2R and ferritin concentrations at baseline. Over time, IL-2R and ferritin concentrations decreased in patients with hypercalcemia, some treated with immunomodulatory drugs. IL-2R and ferritin concentrations increased in untreated patients with normocalcemia.

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来源期刊

Bone 医学-内分泌学与代谢

CiteScore

8.90

自引率

4.90%

发文量

264

审稿时长

30 days

期刊介绍： BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.