治疗性mRNA疫苗在肿瘤学中的应用。

IF 12.1 1区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Molecular Therapy Pub Date : 2025-05-06 DOI:10.1016/j.ymthe.2025.04.044

Leighton Elliott,Timothy Foster,Paul Castillo,Hector Mendez-Gomez,Elias J Sayour

{"title":"治疗性mRNA疫苗在肿瘤学中的应用。","authors":"Leighton Elliott,Timothy Foster,Paul Castillo,Hector Mendez-Gomez,Elias J Sayour","doi":"10.1016/j.ymthe.2025.04.044","DOIUrl":null,"url":null,"abstract":"The emergence of mRNA vaccines for infectious diseases has heralded development for a slew of other indications including cancer. Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to date in clinical development of mRNA cancer vaccines and implications of mRNA localization patterns and biologic response correlates. These advances position emerging mRNA biotechnologies for success against personalized diseases such as cancer.","PeriodicalId":19020,"journal":{"name":"Molecular Therapy","volume":"26 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic mRNA vaccine applications in oncology.\",\"authors\":\"Leighton Elliott,Timothy Foster,Paul Castillo,Hector Mendez-Gomez,Elias J Sayour\",\"doi\":\"10.1016/j.ymthe.2025.04.044\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The emergence of mRNA vaccines for infectious diseases has heralded development for a slew of other indications including cancer. Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to date in clinical development of mRNA cancer vaccines and implications of mRNA localization patterns and biologic response correlates. These advances position emerging mRNA biotechnologies for success against personalized diseases such as cancer.\",\"PeriodicalId\":19020,\"journal\":{\"name\":\"Molecular Therapy\",\"volume\":\"26 1\",\"pages\":\"\"},\"PeriodicalIF\":12.1000,\"publicationDate\":\"2025-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ymthe.2025.04.044\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOTECHNOLOGY & APPLIED MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Therapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ymthe.2025.04.044","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

传染病mRNA疫苗的出现预示着包括癌症在内的一系列其他适应症的发展。脂质颗粒递送载体可以保护RNA免受降解并促进体内递送到预定目标。在这篇小型综述中，我们讨论了mRNA疫苗的机制和增强能力，随后讨论了mRNA癌症疫苗的临床开发进展，以及mRNA定位模式和生物反应相关因素的意义。这些进展使得新兴的mRNA生物技术能够成功对抗个体化疾病，如癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Therapeutic mRNA vaccine applications in oncology.

The emergence of mRNA vaccines for infectious diseases has heralded development for a slew of other indications including cancer. Lipid particle delivery vehicles can protect RNA from degradation and promote delivery to intended targets in vivo. In this mini-review, we discuss mRNA vaccine mechanisms and capacity for enhancement followed by progress to date in clinical development of mRNA cancer vaccines and implications of mRNA localization patterns and biologic response correlates. These advances position emerging mRNA biotechnologies for success against personalized diseases such as cancer.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Molecular Therapy 医学-生物工程与应用微生物

CiteScore

19.20

自引率

3.20%

发文量

357

审稿时长

3 months

期刊介绍： Molecular Therapy is the leading journal for research in gene transfer, vector development, stem cell manipulation, and therapeutic interventions. It covers a broad spectrum of topics including genetic and acquired disease correction, vaccine development, pre-clinical validation, safety/efficacy studies, and clinical trials. With a focus on advancing genetics, medicine, and biotechnology, Molecular Therapy publishes peer-reviewed research, reviews, and commentaries to showcase the latest advancements in the field. With an impressive impact factor of 12.4 in 2022, it continues to attract top-tier contributions.