铜催化clok - wilson重排合成含四取代碳原子的二氢呋喃

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-05-08 DOI:10.1039/d5qo00401b

Qinqin Cui, Shouang Lan, Xiang Lei, Chao Xu, Chunyun Jiang, Lili Zhao, Liyuan Zhou, Jinggong Liu, Cheng-Zhi Gu, Shuang Yang, Xinqiang Fang

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引用次数: 0

摘要

clok - wilson重排法是一种成熟的合成二氢呋喃的方法，但它主要导致二氢呋喃缺乏四取代的立体中心。在本研究中，我们引入了一种铜催化的Cloke-Wilson重排变体，该变体利用1,1,2,2-四取代环丙烷。这种方法允许合成具有四取代立体中心的多种二氢呋喃，产率从良好到优异不等。

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Copper-Catalyzed Cloke-Wilson Rearrangement for the Synthesis of Dihydrofurans Containing Tetrasubstituted Carbon Atoms

The Cloke-Wilson rearrangement is a well-established method for synthesizing dihydrofurans, but it primarily results in dihydrofurans lacking tetrasubstituted stereocenters. In this study, we introduce a copper-catalyzed variant of the Cloke-Wilson rearrangement that utilizes 1,1,2,2-tetrasubstituted cyclopropanes. This approach allows for the synthesis of a diverse range of dihydrofurans featuring tetrasubstituted stereocenters, with yields ranging from good to excellent.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.