Aza-Michael加成-消除-环脱水法合成7-（萘-1-酰基）-吡唑[1,5- A]嘧啶类似物x射线晶体学和结构解析

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI:10.1134/S1070428024604059

T. R. A. Sangma, D. K. Lamin, T. S. Sangma, C. R. Marak, L. B. Marpna, S. Kaping, J. N. Vishwakarma

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引用次数: 0

摘要

1-乙酰萘(1)与二甲基甲酰胺二甲基缩醛反应形成3-（二甲氨基）-1-（萘-1-基）prop-2-en-1-one(2)，在超声照射下与取代氨基吡唑3在KHSO4存在下反应，生成新型取代7-（萘-1-基）吡唑[1,5-a]嘧啶衍生物4a和4b。这些化合物的结构通过分析和光谱数据以及化合物4b的x射线晶体-高阶图分析得到证实。

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A Facile Environment-Friendly Synthesis of 7-(Naphthalen-1-yl)pyrazolo[1,5-a]pyrimidine Analogues via Aza-Michael Addition–Elimination–Cyclodehydration. X-Ray Crystallography and Structural Elucidation

The functionalization of 1-acetylnaphthalene (1) through the reaction with dimethylformamide dimethyl acetal resulted in the formation of 3-(dimethylamino)-1-(naphthalen-1-yl)prop-2-en-1-one (2) which reacted with substituted aminopyrazoles 3 in the presence of KHSO₄ in aqueous media under ultrasonic irradiation, yielding novel substituted 7-(naphthalen-1-yl)pyrazolo[1,5-a]pyrimidine derivatives 4a and 4b. The structures of these compounds were confirmed by analytical and spectral data, as well as by X-ray crystallographic analysis of compound 4b.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.