Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid

In continuation of our studies of modification of fusidane triterpenoids, O-propargyl fragment has been introduced at C³ of fusidic acid methyl ester, and the resulting O-propargyl ether was subjected to copper(I)-catalyzed transformations to obtain aminomethyl, phenylacetylene, and 1,2,3-triazole derivatives.