基于异甜菊醇的双功能硫脲有机催化剂的研究进展

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI:10.1134/S1070428024603662

Yuxia Liu, Zhaoyang Fan, Qi Liu, Mingyang Lv, Xinyu Dai

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引用次数: 0

摘要

将手性1,2-二苯乙二胺（DPEN）引入到异甜菊衍生的硫脲有机催化剂中，促进了芳酮和硝基烯的Michael加成反应。在中性条件下，新型异steviolo - dpen硫脲催化剂具有双重立体选择性控制，Michael加成产物的产率高达98%，对映选择性高达97%。此外，isosteviolo - dpen硫脲催化剂表现出足够的可回收性，并在5次重复使用中保持了立体选择性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes

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Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes

Chiral 1,2-diphenylethylenediamine (DPEN) was introduced into isosteviol-derived thiourea organocatalyst to promote the Michael addition of aromatic ketones and nitroalkenes. Under neutral conditions, the new isosteviol-DPEN thiourea catalyst provides high yield (up to 98%) and enantioselectivity (up to 97%) of the Michael addition products with dual stereoselective control. Furthermore, the isosteviol-DPEN thiourea catalyst showed sufficient recyclability and maintained the stereoselectivity in five reuse cycles.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.