l -脯氨酸在多组分反应合成多取代吡喃衍生物中的催化作用

IF 0.9 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI:10.1134/S1070428024603364

Mugada Sugunakara Rao, M. Ravi Chandra, T. V. S. P. V. Satya Guru

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引用次数: 0

摘要

通过苯甲醛、4-羟基香豆素（二美酮或环己烷-1,3-二酮）和苯甲酰乙腈的原子经济转化，开发了一种操作简单的一锅多组分方案，用于多取代吡喃的组装。这个过程包括l -脯氨酸催化的多米诺骨牌缩合和迈克尔加成。在乙醇中简单混合反应物和催化剂，然后在70℃下加热进行反应，产物在方便的后处理后得到了高产量的分离。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

L-Proline as a Catalyst for the Synthesis of Polysubstituted Pyran Derivatives via Multicomponent Reaction

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L-Proline as a Catalyst for the Synthesis of Polysubstituted Pyran Derivatives via Multicomponent Reaction

An operationally simple, one-pot multicomponent protocol has been developed for the assembly of polysubstituted pyrans via an atom-economic transformation incorporating benzaldehyde, 4-hydroxycoumarin (dimedone, or cyclohexane-1,3-dione), and benzoylacetonitriles. This process involves L-proline-catalyzed domino condensation and Michael addition. The reaction is carried out by simply mixing the reactants and the catalyst in ethanol, followed by heating at 70°C, and the products are isolated in good yields after convenient workup.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.