作为潜在蛋白激酶抑制剂的4-（1h -苯并咪唑-2-基）- n-{3-[（嘧啶-2-基）氨基]苯基}苯酰胺的合成及抗增殖活性

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI:10.1134/S1070428024604679

E. V. Koroleva, A. L. Ermolinskaya, Zh. V. Ignatovich, O. V. Panibrat, Thi-Kim-Dung Hoang, Thi-Kim-Chi Huynh, Thi-Cam-Thu Nguyen

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引用次数: 0

摘要

本文报道了含2-氨基嘧啶和吡啶基团的新型4-（1h -苯并咪唑-2-基）苯酰胺的合成及其抗增殖活性的研究结果。N-（嘧啶-2-基）-间苯二胺与4-（1h -苯并咪唑-2-基）苯甲酰氯酰化或4-（1h -苯并咪唑-2-基）苯甲酸与相同的胺水解得到目标化合物。合成的化合物对稳定的人肿瘤细胞系K562、HL-60、RPMI 1788和HeLa的体外抗增殖活性进行了评价。

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Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors

The results of studying the synthesis and antiproliferative activity of new 4-(1H-benzimidazol-2-yl)benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target compounds were obtained by the acylation of N-(pyrimidin-2-yl)-m-phenylenediamines with 4-(1H-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1H-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.