香豆素和喹啉取代的s-三嗪衍生物的钯催化铃木偶联合成及抑菌评价

IF 0.8 4区化学 Q4 CHEMISTRY, ORGANIC

Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI:10.1134/S1070428024603534

J. B. Mahyavanshi, J. V. Pandya, M. R. Solanki

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引用次数: 0

摘要

设计了一种新的高效合成途径，通过钯催化的铃木偶联反应制备了4-{4-苯胺-6-[（喹啉-8-基）氧]-1,3,5-三嗪-2-基}苯并腈和4-{4-苯胺-6-[（2-氧- 2h -1-苯并吡喃-8-基）氧]-1,3,5-三嗪-2-基}苯并腈。这种方法可以精确合成s-三嗪衍生物。体外抗结核分枝杆菌H37Rv试验显示出显著的效果，特别是香豆素衍生物。通过IR、¹H、¹³C NMR和质谱分析，确定了产物的结构和纯度。

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Strategic Synthesis and Antimycobacterial Evaluation of Coumarin- and Quinoline-Substituted s-Triazine Derivatives via Palladium-Catalyzed Suzuki Coupling

A novel and efficient synthetic pathway was devised for the preparation of 4-{4-anilino-6-[(quinolin-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles and 4-{4-anilino-6-[(2-oxo-2H-1-benzopyran-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles via palladium-catalyzed Suzuki coupling reaction. This approach allowed precise synthesis of s-triazine derivatives. In vitro antimycobacterial testing against Mycobacterium tuberculosis H37Rv demonstrated notable efficacy, especially of the coumarin derivatives. The structural identity and purity of the products were confirmed through IR, ¹H and ¹³C NMR, and mass spectrometry.

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来源期刊

Russian Journal of Organic Chemistry 化学-有机化学

CiteScore

1.40

自引率

25.00%

发文量

139

审稿时长

3-6 weeks

期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.