一项基于登记的研究：2006-2019年瑞典肉芽肿病合并多血管炎的发病率和患病率

IF 4.6 2区医学 Q1 RHEUMATOLOGY

Seminars in arthritis and rheumatism Pub Date : 2025-05-02 DOI:10.1016/j.semarthrit.2025.152745

Karin Wadström , Ola Börjesson , John Moshtaghi-Svensson , Annette Bruchfeld , Iva Gunnarsson , Marie Holmqvist

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引用次数: 0

摘要

目的调查2006年1月1日至2019年12月31日期间瑞典全国肉芽肿病合并多血管炎（GPA）的发病率和患病率，该研究基于登记册，包括整个瑞典人口。方法在以人群为基础的国家患者登记册（NPR）中，我们确定了2006-2019年期间发生和流行GPA的患者。估计年龄和性别标准化的年发病率和粗期患病率。结果按年龄、性别和季节分层。结果在研究期间，我们确定了2013名具有事件GPA的个体。中位年龄为63岁（IQR 51-72）， 46%为女性。平均标准化发病率为1.9 / 10万人-年（95% CI 1.8-2.0），男性发病率为2.0 (95% CI 1.9 - 2.2)，略高于女性的1.7 （95% CI 1.6-1.8）。我们注意到70-79岁年龄组发病率最高，为4.1（95%,3.7-4.5）。在研究期间，年发病率在1.7-2.0范围内保持稳定。我们没有发现发病率有任何季节变化。根据我们确定的2132例流行病例，2019年12月31日的点流行率为25.4 / 10万（95% CI 24.3-26.5）。期间患病率从2006-2010年的18.7 / 10万（95% CI 17.8-19.1）增加到2016-2019年的23.9 / 10万（95% CI 22.8-25.0）。我们的估计表明，瑞典的GPA发病率在2006-2019年期间保持稳定，这与瑞典南部公布的数据一致。在研究期间，患病率增加，这可能是由于治疗的改善导致生存率增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Incidence and prevalence of granulomatosis with polyangiitis in Sweden, 2006–2019, a register-based study

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Incidence and prevalence of granulomatosis with polyangiitis in Sweden, 2006–2019, a register-based study

Objective

To investigate incidence and prevalence of granulomatosis with polyangiitis (GPA) in Sweden nationwide between 1 January 2006 until 31 December 2019 in a register-based study including the entire Swedish population.

Method

In the population-based National Patient Register (NPR) we identified patients with incident and prevalent GPA during the period 2006–2019. Age- and sex standardized annual incidence and crude period prevalence were estimated. Results were stratified on age, sex, and season.

Results

We identified 2013 individuals with incident GPA during the study period. Median age was 63 years (IQR 51–72) and 46 % were women. The mean standardized incidence was 1.9 per 100,000 person-years (95 % CI 1.8–2.0), with a slightly higher incidence in men 2.0 (95 % CI 1.9–2.2) than in women 1.7 (95 % CI 1.6–1.8). We noted the highest incidence in the group aged 70–79, 4.1 (95 % 3.7–4.5). The annual incidence remained stable over the study period range 1.7–2.0. We could not find any seasonal variation in incidence. The point prevalence on December 31st, 2019, was 25.4 per 100,000 (95 % CI 24.3–26.5) based on the 2132 individuals we identified as prevalent. The period prevalence increased from 18.7 per 100,000 (95 % CI 17.8–19.1) in 2006–2010 to 23.9 per 100,000 (95 % CI 22.8–25.0) in 2016–2019.

Conclusion

Our estimates show that incidence of GPA has been stable over the period 2006–2019 in Sweden which are in line with published data from southern Sweden. The prevalence increased during the study period which could be due to improvement in treatment leading to an increased survival.

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来源期刊

Seminars in arthritis and rheumatism 医学-风湿病学

CiteScore

9.20

自引率

4.00%

发文量

176

审稿时长

46 days

期刊介绍： Seminars in Arthritis and Rheumatism provides access to the highest-quality clinical, therapeutic and translational research about arthritis, rheumatology and musculoskeletal disorders that affect the joints and connective tissue. Each bimonthly issue includes articles giving you the latest diagnostic criteria, consensus statements, systematic reviews and meta-analyses as well as clinical and translational research studies. Read this journal for the latest groundbreaking research and to gain insights from scientists and clinicians on the management and treatment of musculoskeletal and autoimmune rheumatologic diseases. The journal is of interest to rheumatologists, orthopedic surgeons, internal medicine physicians, immunologists and specialists in bone and mineral metabolism.