{"title":"通过光催化烯酸烷氧羰基化/内酯化制备酯取代γ-丁内酯","authors":"Yuping Xiong , Ping Liang , Wenlin Xie , Jian-Qiang Chen , Jie Wu","doi":"10.1039/d5qo00520e","DOIUrl":null,"url":null,"abstract":"<div><div>We reported a versatile and concise method to realize the photoredox-induced alkoxycarbonylative lactonization of alkenoic acids for the construction of ester-substituted γ-butyrolactones. This method achieves a multistep cascade reaction by combining photoinduced alkoxycarbonyl radical addition, single-electron oxidization, and lactonization. The reaction shows good compatibility of functional groups with a diverse range of alkoxycarbonyl radical precursors, enabling the efficient introduction of an ester group into the γ-butyrolactone scaffold.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 18","pages":"Pages 5039-5044"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Access to ester-substituted γ-butyrolactones via photocatalyzed alkoxycarbonylation/lactonization of alkenoic acids†\",\"authors\":\"Yuping Xiong , Ping Liang , Wenlin Xie , Jian-Qiang Chen , Jie Wu\",\"doi\":\"10.1039/d5qo00520e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>We reported a versatile and concise method to realize the photoredox-induced alkoxycarbonylative lactonization of alkenoic acids for the construction of ester-substituted γ-butyrolactones. This method achieves a multistep cascade reaction by combining photoinduced alkoxycarbonyl radical addition, single-electron oxidization, and lactonization. The reaction shows good compatibility of functional groups with a diverse range of alkoxycarbonyl radical precursors, enabling the efficient introduction of an ester group into the γ-butyrolactone scaffold.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 18\",\"pages\":\"Pages 5039-5044\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412925003237\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412925003237","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Access to ester-substituted γ-butyrolactones via photocatalyzed alkoxycarbonylation/lactonization of alkenoic acids†
We reported a versatile and concise method to realize the photoredox-induced alkoxycarbonylative lactonization of alkenoic acids for the construction of ester-substituted γ-butyrolactones. This method achieves a multistep cascade reaction by combining photoinduced alkoxycarbonyl radical addition, single-electron oxidization, and lactonization. The reaction shows good compatibility of functional groups with a diverse range of alkoxycarbonyl radical precursors, enabling the efficient introduction of an ester group into the γ-butyrolactone scaffold.