破译混合脂质和蛋白质的语言

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in structural biology Pub Date : 2025-05-07 DOI:10.1016/j.sbi.2025.103061

Michael Overduin , Rakesh Bhat , Thibaud Dieudonné , Peijun Zhang , Troy A. Kervin

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引用次数: 0

摘要

每个细胞都拥有一个遗传密码和一个蛋白脂密码，它们在一个永恒的循环中共同传递分子信息。这个循环的一个要素是识别脂质，这些脂质共同作用，指定生化活动的亚细胞位置。这些“脂质子”现在正在真核生物质膜、核内体、线粒体、原核生物和病毒的蛋白质结构中通过原位冷冻电子成像和膜活性聚合物等技术进行分解。这增加了一个不断扩大的编码蛋白质-脂质相互作用目录，重新背景化细胞生物学和药物发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Deciphering the language of mingling lipids and proteins

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Deciphering the language of mingling lipids and proteins

Each cell possesses a genetic and a proteolipid code that together convey molecular information in a perpetual cycle. One element of this cycle is the recognition of lipids that work together to specify subcellular locations for biochemical activity. These “lipidons” are now being resolved in protein structures from eukaryotic plasma membranes, endosomes, mitochondria, prokaryotes, and viruses with technologies like in situ cryo-electron imaging and membrane-active polymers. This adds to an expanding catalogue of codified protein-lipid interactions that are recontextualizing cell biology and drug discovery.

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来源期刊

Current opinion in structural biology 生物-生化与分子生物学

CiteScore

12.20

自引率

2.90%

发文量

179

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation