芬兰一所大学医院因用药过量而急诊就诊

IF 2.7 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Sami Mustajoki, Aleksi Reito, Kalle Peltonen
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引用次数: 0

摘要

最近没有来自北欧国家的报告描述因药物过量而就诊的急诊科(ED)。所有2021年在芬兰坦佩雷大学医院急诊科就诊且ICD-10编码为T36-T50.9的患者均纳入本研究。共有631名患者进行了803次急诊科就诊,占2021年所有急诊科就诊的0.7%。过量用药的目的是自残的占70%,醉酒的占17%,其他的占13%。患者平均年龄为35岁(1-95岁),其中63%为女性。在52%的就诊中,患者服用了一种以上的药物。苯二氮卓类药物占40%,其次是抗精神病药(28%)、抗抑郁药(19%)、扑热息痛(15%)和阿片类药物(13%)。26%的患者被送进了重症监护室或高依赖性监护室,但没有与过量用药相关的院内死亡。用药过量后1年的总死亡率为2.8%。服药过量的目的通常是自残,其次是醉酒。超过一半的过量用药是多种药物过量,主要使用精神活性药物。没有与药物过量有关的院内死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Emergency Department Visits due to Medication Overdose in a Finnish University Hospital

There are no recent reports from the Nordic countries describing emergency department (ED) visits due to medication overdose.

All patients visiting EDs of Tampere University Hospital, Finland, with ICD-10 codes T36–T50.9 during the year of 2021 were included in this study.

A total of 803 ED visits by 631 individual patients were identified, comprising 0.7% of all ED visits in 2021. The intention of the overdose was self-harm in 70%, inebriation in 17% and other in 13% of the visits. The mean age of the patients was 35 (range 1–95) years, and 63% were female. In 52% of the visits, the patient had taken more than one medication. Benzodiazepines were involved in 40% of the visits, followed by antipsychotics (28%), antidepressants (19%), paracetamol (15%) and opiates (13%). Twenty-six percent of the patients were admitted to the intensive care or high-dependency care unit, but there were no overdose-related in-hospital deaths. The overall 1-year mortality rate after an overdose was 2.8%.

The intention of a medication overdose was most often self-harm, followed by inebriation. Over half of the overdoses were multidrug overdoses, and psychoactive medications were predominantly used. There were no in-hospital deaths related to medication overdoses.

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来源期刊
CiteScore
5.60
自引率
6.50%
发文量
126
审稿时长
1 months
期刊介绍: Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
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