{"title":"t细胞大颗粒淋巴细胞白血病的流行病学、生存率和第二原发恶性肿瘤","authors":"Arya Mariam Roy, Sawyer Bawek, Richa Parikh, Muhammad Salman Faisal, Paola Ghione","doi":"10.1002/jha2.70036","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Patients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.</p>\n </section>\n \n <section>\n \n <h3> Trial Registration</h3>\n \n <p>The authors have confirmed clinical trial registration is not needed for this submission</p>\n </section>\n </div>","PeriodicalId":72883,"journal":{"name":"EJHaem","volume":"6 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jha2.70036","citationCount":"0","resultStr":"{\"title\":\"Epidemiology, Survival, and Second Primary Malignancies in T-Cell Large Granular Lymphocytic Leukemia\",\"authors\":\"Arya Mariam Roy, Sawyer Bawek, Richa Parikh, Muhammad Salman Faisal, Paola Ghione\",\"doi\":\"10.1002/jha2.70036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Patients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Trial Registration</h3>\\n \\n <p>The authors have confirmed clinical trial registration is not needed for this submission</p>\\n </section>\\n </div>\",\"PeriodicalId\":72883,\"journal\":{\"name\":\"EJHaem\",\"volume\":\"6 3\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jha2.70036\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"EJHaem\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/jha2.70036\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"EJHaem","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/jha2.70036","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Epidemiology, Survival, and Second Primary Malignancies in T-Cell Large Granular Lymphocytic Leukemia
Introduction
Large granular lymphocytic leukemia (LGL) is a rare lymphoproliferative disorder, with limited literature available about the epidemiology, survival, and development of secondary primary malignancies (SPMs) in T-LGL.
Methods
The Surveillance, Epidemiology, and End Results (SEER) 17 registry was used to identify all cases of T-LGL diagnosed between 2000 and 2019, and patients with primary T-LGL were analyzed.
Results
Patients with primary T-LGL were found to have a higher incidence of SPMs compared to the general population, with increased risk for hematological malignancies seen within the first 10 years and solid tumors seen after 10 years of T-LGL diagnosis.
Conclusion
Patients with primary T-LGL were found to have a higher incidence of SPMs. Further research is needed to better understand the reason for this increased risk.
Trial Registration
The authors have confirmed clinical trial registration is not needed for this submission
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