肽键反击

IF 2.9 2区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

IUCrJ Pub Date : 2025-05-01 DOI:10.1107/S2052252525003604

Ashwin Chari

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引用次数: 0

摘要

蛋白质设计和蛋白质结构预测的最新进展质疑实验结构生物学在今天的研究中是否仍然发挥作用。潘吉卡和韦斯的文章[(2025)]。IUCrJ, 12, 307-321]部分回答了这个问题，并暗示了结构生物学仍在发挥作用。肽键的几个特性可能对功能很重要，这些特性在蛋白质设计和预测蛋白质结构中是不存在的，并且在很大程度上被结构生物学界所忽视。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Peptide bonds strike back

Recent advances in protein design and protein structure prediction have questioned whether experimental structural biology still has a role to play in research today. The article by Panjikar and Weiss [(2025). IUCrJ, 12, 307–321] partially answers this question and alludes to a role still to be played by structural biology. Several properties of peptide bonds, likely important for function, are described that are absent in protein design and predicted protein structures, and that have largely been overlooked by the structural biology community.

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来源期刊

IUCrJ CHEMISTRY, MULTIDISCIPLINARYCRYSTALLOGRAPH-CRYSTALLOGRAPHY

CiteScore

7.50

自引率

5.10%

发文量

审稿时长

10 weeks

期刊介绍： IUCrJ is a new fully open-access peer-reviewed journal from the International Union of Crystallography (IUCr). The journal will publish high-profile articles on all aspects of the sciences and technologies supported by the IUCr via its commissions, including emerging fields where structural results underpin the science reported in the article. Our aim is to make IUCrJ the natural home for high-quality structural science results. Chemists, biologists, physicists and material scientists will be actively encouraged to report their structural studies in IUCrJ.