离子对介导的受阻氟烷基化合物合成中有机硼的双重活化

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-24 DOI:10.1021/acs.orglett.5c0112710.1021/acs.orglett.5c01127

Soo Young Kim, Juho Lee, Won Seok Ham, Tae Yeong Im, Su Yong Go and Hong Geun Lee*,

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引用次数: 0

摘要

提出了一种新的电化学合成受阻烷基氟化合物的方法。该议定书允许在温和条件下使用容易获得的有机硼前体获得各种各样的叔和仲烷基氟化物。系统的效率源于氧化还原活性硼酸盐中间体的双重激活，以内部生成的离子对的形式提供亲电和亲核反应伙伴。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dual Activation of Organoboron for the Ion-Pair-Mediated Synthesis of Hindered Alkyl Fluorides

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Dual Activation of Organoboron for the Ion-Pair-Mediated Synthesis of Hindered Alkyl Fluorides

A novel electrochemical approach for the synthesis of hindered alkyl fluorides has been developed. The protocol grants access to a diverse array of tertiary and secondary alkyl fluorides using readily attainable organoboron precursors under mild conditions. The efficiency of the system stems from the dual activation of the redox-active borate intermediate, providing both electrophilic and nucleophilic reaction partners in the form of an internally generated ion pair.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.