染色体外DNA指南：癌症的动态环状基因组

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-04-27 DOI:10.1158/2159-8290.cd-25-0230

Natasha E. Weiser, Thomas B.K. Watkins, Howard Y. Chang, Paul S. Mischel

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引用次数: 0

摘要

癌基因的局灶扩增是重要的癌症驱动因素。它们可以发生在染色体上或在环状染色体外DNA （ecDNA）的背景下。ecdna的许多关键特征在20世纪60年代至80年代被描述，包括它们的“不稳定”性质和赋予耐药性的能力。随着新技术的发展，我们对ecdna的理解在过去十年中无论是在广度还是深度上都有了显著的进步，包括发现17%的癌症中存在ecdna，并且与更糟糕的患者预后相关。在本研究中，我们介绍了ecDNA工具和生物学的指南。意义：ecDNAs的局灶扩增常见于癌症，并与不良的患者预后和不同的生物学相关。在这篇综述中，我们提供了ecDNA生物学的指南和可用的工具，以及我们对这一快速发展的领域的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A Guide to Extrachromosomal DNA: Cancer’s Dynamic Circular Genome

Focal amplifications of oncogenes are important cancer drivers. They can occur on chromosomes or in the context of circular extrachromosomal DNA (ecDNA). Many key features of ecDNAs were described in the 1960s to 1980s, including their “unstable” nature and their ability to confer drug resistance. With the benefit of new technologies, our understanding of ecDNAs has advanced dramatically in the last decade, both in breadth and in depth, including the remarkable discovery that ecDNAs are present in 17% of all cancers and are associated with worse patient outcomes. In this study, we present a guide to ecDNA tools and biology. Significance: Focal amplifications on ecDNAs are commonly found in cancer and are associated with poor patient outcomes and distinct biology. In this review, we provide a guide to ecDNA biology and available tools as well as our perspective on this rapidly evolving field.

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.