马拉维儿童发热性昏迷的病因学、神经放射学特征和死亡率及长期神经后遗症的危险因素：一项前瞻性队列研究

IF 19.9 1区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Lancet Global Health Pub Date : 2025-04-22 DOI:10.1016/s2214-109x(25)00054-3

Stephen T J Ray PhD, Charlotte E Fuller MRCPCH, Ajisa Ahmadu BSc, Edith Kafoteka BSc, Alice Muiruri-Liomba MPH, Albert Malenga BScPH, Andrew Tebulo DCM, Paul Pensulo BScPCH, Monfort B Gushu BScPH, Cowles Chilingulo BSc, Reena Dwivedi MSc, Karen Chetcuti MSc, Charalampos Attipa PhD, Rachel Byrne PhD, Maryke Nielsen MSc, Jon Rigby PhD, Elisabeth Stockdale MRCPCH, Alex Boubour MSc, Marc Y R Henrion PhD, Josephine Langton MBChB, Catherine Anscombe PhD, Janet Flatley PhD, Tessa Prince PhD, Shivram Avula PhD, Prof Gretchen L Birbeck MD, Douglas G Postels MD, Nicole O'Brien MD, Jennifer Cornick PhD, Prof Benedict D Michael PhD, Prof Tom Solomon FMedSci, Prof Melissa Gladstone PhD, Prof Stephen B Gordon MD, Yamikani Chimalizeni FCPaed, Prof Terrie Taylor DO, Christopher A Moxon PhD, Prof David G Lalloo PhD, Prof Karl Seydel MD PhD, Prof Michael J Griffiths DPhil

{"title":"马拉维儿童发热性昏迷的病因学、神经放射学特征和死亡率及长期神经后遗症的危险因素：一项前瞻性队列研究","authors":"Stephen T J Ray PhD, Charlotte E Fuller MRCPCH, Ajisa Ahmadu BSc, Edith Kafoteka BSc, Alice Muiruri-Liomba MPH, Albert Malenga BScPH, Andrew Tebulo DCM, Paul Pensulo BScPCH, Monfort B Gushu BScPH, Cowles Chilingulo BSc, Reena Dwivedi MSc, Karen Chetcuti MSc, Charalampos Attipa PhD, Rachel Byrne PhD, Maryke Nielsen MSc, Jon Rigby PhD, Elisabeth Stockdale MRCPCH, Alex Boubour MSc, Marc Y R Henrion PhD, Josephine Langton MBChB, Catherine Anscombe PhD, Janet Flatley PhD, Tessa Prince PhD, Shivram Avula PhD, Prof Gretchen L Birbeck MD, Douglas G Postels MD, Nicole O'Brien MD, Jennifer Cornick PhD, Prof Benedict D Michael PhD, Prof Tom Solomon FMedSci, Prof Melissa Gladstone PhD, Prof Stephen B Gordon MD, Yamikani Chimalizeni FCPaed, Prof Terrie Taylor DO, Christopher A Moxon PhD, Prof David G Lalloo PhD, Prof Karl Seydel MD PhD, Prof Michael J Griffiths DPhil","doi":"10.1016/s2214-109x(25)00054-3","DOIUrl":null,"url":null,"abstract":"Children in febrile coma in Africa are frequently hospitalised, with poorer outcomes than those in high-income settings. Cerebral malaria is historically the most common cause of febrile coma. Due to limited diagnostic and radiological resources and a decrease in malaria prevalence, there might be under-recognition of non-malarial coma. However, prospective data are scarce. We aimed to determine causes, neuroradiological features, risk factors for mortality, and neurosequelae of children in febrile coma in Malawi.","PeriodicalId":48783,"journal":{"name":"Lancet Global Health","volume":"80 1","pages":""},"PeriodicalIF":19.9000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study\",\"authors\":\"Stephen T J Ray PhD, Charlotte E Fuller MRCPCH, Ajisa Ahmadu BSc, Edith Kafoteka BSc, Alice Muiruri-Liomba MPH, Albert Malenga BScPH, Andrew Tebulo DCM, Paul Pensulo BScPCH, Monfort B Gushu BScPH, Cowles Chilingulo BSc, Reena Dwivedi MSc, Karen Chetcuti MSc, Charalampos Attipa PhD, Rachel Byrne PhD, Maryke Nielsen MSc, Jon Rigby PhD, Elisabeth Stockdale MRCPCH, Alex Boubour MSc, Marc Y R Henrion PhD, Josephine Langton MBChB, Catherine Anscombe PhD, Janet Flatley PhD, Tessa Prince PhD, Shivram Avula PhD, Prof Gretchen L Birbeck MD, Douglas G Postels MD, Nicole O'Brien MD, Jennifer Cornick PhD, Prof Benedict D Michael PhD, Prof Tom Solomon FMedSci, Prof Melissa Gladstone PhD, Prof Stephen B Gordon MD, Yamikani Chimalizeni FCPaed, Prof Terrie Taylor DO, Christopher A Moxon PhD, Prof David G Lalloo PhD, Prof Karl Seydel MD PhD, Prof Michael J Griffiths DPhil\",\"doi\":\"10.1016/s2214-109x(25)00054-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Children in febrile coma in Africa are frequently hospitalised, with poorer outcomes than those in high-income settings. Cerebral malaria is historically the most common cause of febrile coma. Due to limited diagnostic and radiological resources and a decrease in malaria prevalence, there might be under-recognition of non-malarial coma. However, prospective data are scarce. We aimed to determine causes, neuroradiological features, risk factors for mortality, and neurosequelae of children in febrile coma in Malawi.\",\"PeriodicalId\":48783,\"journal\":{\"name\":\"Lancet Global Health\",\"volume\":\"80 1\",\"pages\":\"\"},\"PeriodicalIF\":19.9000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lancet Global Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/s2214-109x(25)00054-3\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lancet Global Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/s2214-109x(25)00054-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

摘要

非洲的发热性昏迷儿童经常住院，其预后比高收入国家的儿童差。脑疟疾历来是发热性昏迷的最常见原因。由于有限的诊断和放射资源以及疟疾患病率的下降，可能对非疟疾性昏迷的认识不足。然而，前瞻性的数据是稀缺的。我们旨在确定马拉维儿童发热性昏迷的病因、神经放射学特征、死亡危险因素和神经后遗症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Aetiologies, neuroradiological features, and risk factors for mortality and long-term neurosequelae of febrile coma in Malawian children: a prospective cohort study

Children in febrile coma in Africa are frequently hospitalised, with poorer outcomes than those in high-income settings. Cerebral malaria is historically the most common cause of febrile coma. Due to limited diagnostic and radiological resources and a decrease in malaria prevalence, there might be under-recognition of non-malarial coma. However, prospective data are scarce. We aimed to determine causes, neuroradiological features, risk factors for mortality, and neurosequelae of children in febrile coma in Malawi.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Lancet Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

44.10

自引率

1.20%

发文量

763

审稿时长

10 weeks

期刊介绍： The Lancet Global Health is an online publication that releases monthly open access (subscription-free) issues.Each issue includes original research, commentary, and correspondence.In addition to this, the publication also provides regular blog posts. The main focus of The Lancet Global Health is on disadvantaged populations, which can include both entire economic regions and marginalized groups within prosperous nations.The publication prefers to cover topics related to reproductive, maternal, neonatal, child, and adolescent health; infectious diseases (including neglected tropical diseases); non-communicable diseases; mental health; the global health workforce; health systems; surgery; and health policy.