非重氮法通过给体/给体铂卡贝烯催化生成邻醌二甲醚

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-27 DOI:10.1021/acs.orglett.5c01508

Jun-Jie Hao, Tao Jiang, FuJunyang Wu, Hejiang Luo, Rong-Tao Li

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引用次数: 0

摘要

采用铂催化烯酮与各种亲二酚类化合物的反应，构建了四氢萘衍生物，并与铂羰基和邻醌二甲醚（o-QDM）中间体进行Diels-Alder反应。在本方案中，烷氧基取代的共轭炔被用作生成o- qdm的非重氮碳前体，从而扩展了生成o- qdm的可用方法。该反应具有原子经济性高、非对映选择性强、底物范围广等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Catalytic Generation of o-Quinone Dimethides by a Nondiazo Approach via Donor/Donor Platinum Carbenes

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Catalytic Generation of o-Quinone Dimethides by a Nondiazo Approach via Donor/Donor Platinum Carbenes

A platinum-catalyzed reaction of enynones with various dienophiles has been developed for the construction of tetrahydronaphthalene derivatives, which undergo a Diels–Alder reaction process with platinum carbenes and o-quinone dimethide (o-QDM) intermediates. In this protocol, an alkoxy-substituted conjugated enynone is used as a nondiazo carbene precursor for the generation of o-QDMs, thereby extending the methods available for the generation of o-QDMs. The reaction is characterized by its high atom economy, high diastereoselectivity, and broad substrate scope.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.