通过锌克亚胺对取代的吡啶进行元选择性硫代氟烷基化反应

Organic chemistry frontiers : an international journal of organic chemistry Pub Date : 2025-04-28 DOI:10.1039/d5qo00533g

Will C. Hartley , Arnau Huerta , Júlia C. Negredo , Omar Boutureira

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引用次数: 0

摘要

锌克亚胺使取代吡啶的区域选择性硫代氟烷基化，光栅获得具有一系列氟化模式的硫代烷基化吡啶。这一战略取得成功的关键是使用了糖精衍生的硫代氟烷基化试剂，这些试剂与tmsl反应后产生亲电性亚砜酰氯。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines†

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meta-Selective thiofluoroalkylation of substituted pyridines via Zincke imines†

Zincke imines enable the regioselective thiofluoroalkylation of substituted pyridines, providing access to thioalkylated pyridines bearing a range of fluorination patterns. Crucial to the success of this strategy was the use of saccharine-derived thiofluoroalkylating reagents, which, upon reaction with TMSCl, generate electrophilic sulfenyl chlorides.

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来源期刊

Organic chemistry frontiers : an international journal of organic chemistry

CiteScore

7.80

自引率

0.00%

发文量