铜催化醛类有氧氧化生成羧酸

IF 4.6 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-04-26 DOI:10.1039/d5qo00330j

Yankai Huang, Sheng Jiang, Zhengnan Zhengnan Zhou, Yibo Yu, Hui Qian, Shengming Ma

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引用次数: 0

摘要

利用氧或空气作为氧化剂，开发了一种有效、实用的醛类有氧氧化制羧酸的方法。在室温条件下，以Cu(NO3)2·3H2O和TEMPO的催化量进行反应，并可耐受烷基、氨基、芳基等多种有用官能团。含有多个醛基的复杂分子和化合物可用于该反应，具有很好的选择性。克级反应很容易进行。

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Copper catalyzed aerobic oxidation of aldehydes to carboxylic acids

An efficient practical aerobic oxidation of aldehydes to carboxylic acids using O2 or air as the oxidant has been developed. The reaction was carried out with a catalytic amount each of Cu(NO3)2·3H2O and TEMPO at room temperature tolerating many useful functional groups such as alkynyl, amino, aryl, etc. Complex molecules and compounds containing multiple aldehyde groups are applicable to this reaction with an excellent selectivity. Gram scale reactions have been easily conducted.

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.