通过1,10-菲罗啉和亚胺的电还原环化在室温下获得桥接氮配体

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-04-25 DOI:10.1021/acs.orglett.5c01140

Chengqian Zhang, Maorui Wang, Min Zhang

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引用次数: 0

摘要

建立了1,10-菲罗啉与亚胺的电还原环化反应。该方法具有广泛的底物和功能耐受性，高选择性，并且不需要加压氢气或过渡金属催化剂。机理研究表明，该产物是通过质子活化的反应物同时电还原，然后进行自由基交叉偶联和偶联加合物的分子内环化而形成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Room Temperature Access to Bridged Nitrogen Ligands via Electroreductive Annulation of 1,10-Phenanthrolines and Imines

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Room Temperature Access to Bridged Nitrogen Ligands via Electroreductive Annulation of 1,10-Phenanthrolines and Imines

An electroreductive annulation reaction of 1,10-phenanthrolines and imines has been developed. This method proceeds with broad substrate and functionality tolerance, high selectivity, and no need for pressurized H₂ gas or transition metal catalysts. Mechanistic studies reveal that the products are formed via simultaneous electroreduction of both proton-activated reactants followed by radical cross-coupling and intramolecular cyclization of the coupling adduct.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.