饥饿诱导代谢性肝细胞重编程

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-04-25 DOI:10.1038/s42255-025-01286-x

Coenraad F. Slabber, Jan S. Tchorz

引用次数: 0

摘要

肝脏在长时间禁食和饥饿期间进行糖异生，即葡萄糖的重新产生。Okada等人的一项研究现在强调了在摄食状态之间的代谢转换过程中肝细胞的时空代谢重编程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Starvation induces metabolic hepatocyte reprogramming

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Starvation induces metabolic hepatocyte reprogramming

The liver performs gluconeogenesis, the de novo production of glucose during extended fasting and starvation. A study by Okada et al. now highlights spatiotemporal metabolic reprogramming in hepatocytes during metabolic transitions between feeding states.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.