液体活检中来自噪声的CHIP信号。

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2025-04-24 DOI:10.1158/1078-0432.ccr-25-0569

Elsa Bernard,Jean-Baptiste Micol

引用次数: 0

摘要

无细胞DNA （cfDNA）分析中克隆造血（CH）的存在会扭曲结果的解释并影响癌症治疗决策。本CCR翻译讨论了区分cfDNA变异为肿瘤或造血起源的重要性及其潜在的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

CHIP'ing Signal from Noise in Liquid Biopsy.

The presence of clonal hematopoiesis (CH) in cell-free DNA (cfDNA) analysis can distort the interpretation of results and impact cancer treatment decisions. This CCR Translations discusses the importance of distinguishing the origin of cfDNA variants as tumoral or hematopoietic and its potential clinical implications.

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来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.