女性生殖道中肾样腺癌：病理诊断、临床结果和新的治疗方法

IF 4.5 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Gynecologic oncology Pub Date : 2025-04-24 DOI:10.1016/j.ygyno.2025.04.583

Kari L. Ring , Anne M. Mills , Brooke E. Howitt , Rachel N. Grisham , Elizabeth D. Euscher , Hyun-Soo Kim , Ann H. Klopp , David L. Kolin , W. Glenn McCluggage , Jelena Mirkovic , Kay J. Park , Eliane Aoun , Chika Awujo , Ji Son , Samuel C. Mok , Sammy Ferri-Borgogno , David S. Hong , Lien Hoang , Amir A. Jazaeri , Jeffrey A. How , Karen H. Lu

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引用次数: 0

摘要

2016年，McCluggage及其同事首次定义了子宫和子宫外部位的间肾样腺癌（MLA）。根据这一初步描述，世界卫生组织正式承认MLA是一种子宫癌和卵巢癌，随后的研究进一步完善了这一罕见实体的形态学定义、免疫组织化学特征、分子基础和临床行为。一个由病理学家、妇科肿瘤学家、医学肿瘤学家、放射肿瘤学家以及具有MLA专业知识的基础科学合作者组成的联盟被召集起来，就病理诊断达成共识，并确定未解决的问题和优先研究领域。在这里，我们从病理、分子和临床的角度回顾目前对MLA的理解。

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Mesonephric-like adenocarcinoma of the female genital tract: Pathologic diagnosis, clinical outcomes, and novel therapeutics

In 2016, McCluggage and colleagues first defined mesonephric-like adenocarcinoma (MLA) of the uterus and extra-uterine sites. Following this initial description, the World Health Organization officially recognized MLA as a type of uterine and ovarian carcinoma and subsequent studies have further refined the morphologic definition, immunohistochemical profile, molecular underpinnings, and clinical behavior in this rare entity. A consortium of pathologists, gynecologic oncologists, medical oncologists, radiation oncologists, as well as basic science collaborators with expertise in MLA was convened to develop consensus regarding the pathologic diagnosis, and to identify unanswered questions and priority areas for research. Here, we review the current understanding of MLA from a pathologic, molecular, and clinical standpoint.

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来源期刊

Gynecologic oncology 医学-妇产科学

CiteScore

8.60

自引率

6.40%

发文量

1062

审稿时长

37 days

期刊介绍： Gynecologic Oncology, an international journal, is devoted to the publication of clinical and investigative articles that concern tumors of the female reproductive tract. Investigations relating to the etiology, diagnosis, and treatment of female cancers, as well as research from any of the disciplines related to this field of interest, are published. Research Areas Include: • Cell and molecular biology • Chemotherapy • Cytology • Endocrinology • Epidemiology • Genetics • Gynecologic surgery • Immunology • Pathology • Radiotherapy